نتایج جستجو برای: familial polyps
تعداد نتایج: 66728 فیلتر نتایج به سال:
Background: Familial adenomatous polyposis (FAP) is the most common components polyposis syndromes. It incidence is for less than 1 percent of colorectal cancer cases. FAP is characterized by germline mutations in the adenomatous polyposis coli (APC) gene. Generally, there are hundreds to thousands of adenomatous polyps in colon and rectum of patients. The aim of the current study was to evalua...
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 inhibitors, have promise as anticancer agents. NSAIDs restore normal apoptosis in human adenomatous colorectal polyps and in various cancer cell lines that have lost adenomatous polyposis coli gene function. NSAIDs also i...
Familial adenomatous polyposis (FAP) is a dominantly inherited predisposition to the development of many hundreds to thousands of adenomatous polyps of the colon. The mean age of onset is around 15 years, symptoms may arise in the third decade, and the median age for the development of colonic cancer is 35-40 years. Prophylactic colectomy reduces the risk of death from colorectal cancer to such...
Sulindac is a nonsteroidal antiinflammatory drug with a chemopreventive effect in patients with familial adenomatous polyposis (FAP). In vivo, the active form of sulindac is sulindac sulfide, which is inactivated by the hepatic microsomal enzyme, flavin monooxygenase 3 (FMO3). In humans, numerous polymorphisms exist in FMO3, which alter enzymatic activity and subsequent substrate metabolism. We...
Background: Most of colorectal cancers (CRC) have originated from intestinal polyps. Evaluating of the expression level of genes that are involved in tumors growth and development, may consider as diagnostic factor of malignancy in the polyps. AXIN2 regulates the level of nuclear β-catenin in a negative-feedback loop there by being a negative regulator and target gene at the same time. The aims...
from june 1989, to june 1991, 58 patients with gi polyps were reviewed. except two patients who had multiple polyps, 56 had only one polyp. the size of polyps were 0.5 to 3 em in diameter. 51 (75%) of polyps were located in the rectosigmoid region, 25 (37%) were in the rectum and 26 (38%) in the sigmoid. (seventeen) (25%) polyps (two in right colon, four in transverse, and 11 in descending colo...
34 children aged 9 months to 12 years presenting with chronic and intermittent rectal bleeding were diagnosed as having colorectal polyps by fiberoptic colonoscopy performed under sedation. bleeding per rectum (mean duration, 15 months) was the chief presenting symptom and was present in 97% of these patients. in 85% of patients polypectomy was carried out without using general anesthesia. 7r% ...
BACKGROUND Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder. Familial testicular cancer in the presence of other findings in affected and unaffected family members might indicate a previously-unidentified hereditary cancer syndrome. CASE PRESENTATION The patient was diagnosed with a left testicular seminoma at age 28, and trea...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید