BB Recurrent miscarriage is a common disorder that affects 1–3% of women of reproductive age; the prevalence can be up to 5% for women with 2 pregnancy losses. In a majority of these women, however, especially in those with early pregnancy losses, the causative factors for pregnancy loss can include chromosomal aberration of the fetus; anatomic abnormalities of the uterus; endocrine disorders, ...

BACKGROUND The complex between activated protein C (APC) and the protein C inhibitor (PCI) is a sensitive indicator of the degree of activation of blood coagulation and higher concentrations have been measured in carriers of the FV Leiden mutation who were in the recovery phase after treatment for venous thromboembolism (VTE). OBJECTIVES The main purpose of this study was to correlate the APC...

Common inherited thrombophilic defects such as factor V Leiden and G20120A mutation of the prothrombin gene interact synergistically with oral contraceptives to increase the risk of venous thromboembolism. 2 The best approach to identify women at higher risk of venous thromboembolism before taking oral contraceptives is controversial. Universal screening is not cost effective because 8000 women...

ground. The frequency of factor V Leiden and of the MTHFR in patients with CVT were 10% (1/10) and 33.3% (3/10), respectively, ie, twice as much as that found in controls (5.8% [15/259] and 17.4% [45/259], respectively). Two patients had the MTHFR genotype and the G20210A PRTH variant simultaneously; 1 carried the PRTH and the factor V Leiden variants. On the whole, 3 patients (33.3%) showed th...

Women with thrombophilia are at an increased risk of not only venous thromboembolism, but various other complications including intrauterine foetal growth retardation, pre-eclampsia and foetal loss. Both inherited and acquired thrombophilias contribute to thrombotic events and their adverse outcome in pregnancy. The major inherited thrombophilias include deficiencies of antithrombin, protein C,...

The risk of spontaneous or risk-period related venous thromboembolism in family members of symptomatic carriers of antithrombin (AT), protein C (PC) or protein S (PS) defects, as well as of the Factor V Leiden mutation is still undefined. We performed a retrospective cohort study in family members (n = 793) of unselected patients with a documented venous thromboembolism and one of these deficie...

A recently described genetic variant of the prothrombin gene (G to A transition at nucleotide position 20210) is associated with an increased risk of venous thrombosis (1). The 20210A prothrombin allele may precipitate cerebral ischemia or myocardial infarction in young patients with known prothrombotic abnormalities (2, 3). Similarly, it has been demonstrated that factor V Leiden further incre...

BACKGROUND AND PURPOSE Factor V Leiden and a prothrombin gene variant, G20210A, are mutations associated with a thrombotic risk. The aim of our study was to assess whether these mutations increase the risk of stroke in women under 45 years of age. METHODS We conducted a case-control study in western Washington state. Case patients were women aged 18 to 44 years with a first stroke (n = 106). ...

Factor V (FV) Leiden is the most common genetic defect found in persons of European descent with venous thromboembolism.1 The 1691G.A transition determines the R506Q substitution.2 This suppresses a cleavage site for activated protein C (APC) on FVa, resulting in resistance to APC in a functional coagulation-based assay.3 FV Leiden accounts for over 90% cases of APC resistance, but this phenome...

BACKGROUND Venous thrombosis is one of the leading causes of maternal morbidity and mortality. OBJECTIVE In the MEGA study, we evaluated pregnancy and the postpartum period as risk factors for venous thrombosis in 285 patients and 857 control subjects. PATIENTS/METHODS Between March 1999 and September 2004, consecutive patients with a first episode of venous thrombosis were included from si...