Ischemic stroke is a heterogeneous multifactorial disease that is affected by several genetic mutations and environmental factors. Various polymorphisms and mutations have been described as risk factors for stroke and they include angiotensin-converting enzyme (ACE) genotype, factor V Leiden, prothrombin G20210A, methylene tetrahydrofolate reductase (MTHFR), human platelet antigen type 1, facto...

background: role of genetic factors in etiology of preeclampsia is not confirmed yet. objective: gene defect frequency varies in different geographic areas as well as ethnic groups. in this study, the role of factor v leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of persian gulf in iran, were considered. materials and methods: betwe...

factor v leiden deficiency is the most common hereditary hypercoagulable disease in the united states and involves 5% of the caucasian population. up to 30% of patients who present with deep vein thrombosis (dvt) or pulmonary thromboembolism present with this condition. this is a case report of a 36-year-old man who experienced one episode of dvt within the previous year and was admitted to our...

1. Goudemand J, Rothschild C, Demiguel V, et al. Influence of the type of factor VIII concentrate on the incidence of factor VIII inhibitors in previously untreated patients with severe hemophilia A. Blood. 2006;107:46-51. 2. Chalmers EA, Brown SA, Keeling D, et al. Early factor VIII exposure and subsequent inhibitor development in children with severe haemophilia A. Haemophilia. 2007;13:149-15...

Inhibitors to factor V is a rare phenomenon with varied clinical presentation ranging from asymptomatic states life-threatening bleeds. They are known be associated exposure bovine thrombin, drugs, autoimmune diseases and malignancies. Establishing the diagnosis of FV inhibitors challenging presence lupus-like properties inhibitor can further complicate diagnosis. Here we document an unusual ca...

BACKGROUND Elderly patients with unstable coronary artery disease (CAD) have better outcomes with coronary revascularization than conservative treatment. With the improvement in percutaneous coronary intervention (PCI) techniques using drug eluting-stents, this became an attractive option in elderly. Minimally invasive coronary artery bypass grafting (MICS-CABG) is a safe and effective alternat...

The anionic phospholipid, phosphatidyl-L-serine (PS), is sequestered in the inner layer of the plasma membrane in normal cells. Upon injury, activation, and apoptosis, PS becomes exposed on the surfaces of cells and sheds microparticles, which are procoagulant. Coagulation is initiated by formation of a tissue factor/factor VIIa complex on PS-exposed membranes and propagated through the assembl...