BACKGROUND Peak oxygen uptake (VO(2peak)) is a strong predictor of cardiovascular disease (CVD) and all-cause mortality, but is inadequately described in patients with schizophrenia. The aim of this study was to evaluate treadmill VO(2peak), CVD risk factors and quality of life (QOL) in patients with schizophrenia (ICD-10, F20-29). METHODS 33 patients, 22 men (33.7 ± 10.4 years) and 11 women ...

Glutathione and the products of its hydrolysis were determined by methods of this laboratory (I) ; glucose was determined by the method of Somogyi (2) and of Nelson (3). Rats were anesthetized with ether, blood was removed from the vena cava, and other tissues were removed, weighed, and immediately homogenized with cold 5 per cent trichloroacetic acid (about 10 ml. per 1 gm.), filtered, and the...

PURPOSE To determine the effects of high-speed eccentric training of rat plantar flexor muscles on: 1) maximum (120 Hz) force at 90 degrees ankle position; 2) fatigue (40 concentric muscle actions, ROM 50 degrees) and recovery (6 concentric muscle actions) tested at short or long muscle lengths; and 3) low-frequency fatigue. METHODS Training consisted of eccentric muscle actions from ankle po...

BACKGROUND The situation for older persons with mental disorders other than dementia disorders has scarcely been studied. The older population is increasing worldwide and along with this increase the prevalence of mental disorders will also rise. The treatment of older persons with mental disorders entails complex challenges, with drugs constituting the major medical treatment. Knowledge of ger...

We have compiled a complete extragalactic sample based on ∼ 25, 000 deg to a limiting flux of 3 × 10 ergs cm s (∼ 7, 000 deg to a flux limit of 10 ergs cm s) in the 20 – 40 keV band with INTEGRAL. We have constructed a detailed exposure map to compensate for effects of non-uniform exposure. The flux-number relation is best described by a power-law with a slope of α = 1.66 ± 0.11. The integratio...

BACKGROUND The court proceedings after the terrorist attacks on 22 July 2011 reignited the debate on the justification for having a rule that regulates the insanity defence exclusively on the basis of a medical condition – the medical principle. The psychological principle represents an alternative that requires a causal relationship between the psychosis and the acts committed. In this article...

Fenoterol HBr is a bronchodilator known to be subject to first pass effect after oral administration. The aim of this study was to prepare and evaluate fenoterol HBr suppositories. Suppositories were prepared by a fusion method using different fatty bases, viz. Witepsol H15, Witepsol E75, Suppocire AP, and Suppocire BM, as well as different hydrophilic bases, viz. polyethylene glycol and poloxa...

Molecular dynamics simulations using the stochastic boundary method were carried out for apoazurin of Alcaligenes denitrifcans. For a region centered on the exposed tryptophyl residue (W118), simulations in vacuo and with inclusion of model water molecules were carried out. The simulations are in accord with the experimental finding that the interior tryptophan (W48) is less mobile than the ext...

BACKGROUND The Health of the Nation Outcomes Scale (HoNOS) is recommended for use by the English National Service Framework for Mental Health and by the working group on outcome indicators for severe mental illnesses to the Department of Health. It was developed to measure the health and social functioning of people with severe mental illness. Since the development of the HoNOS many have debate...

BACKGROUND This article compares needs for care among patients with schizophrenia across six European countries and examines how this relates to the diversity of psychiatric systems in Europe. METHODS A one-year prospective cohort study was set up. Inclusion criteria for patients were: a clinical lifetime diagnosis of schizophrenia according to ICD-10 (F20) diagnostic criteria for research, a...