AIM The aim of this study was to determine if nevus-associated melanoma differs in characteristics and prognosis from de novo melanoma. PATIENTS AND METHODS The study included 118 melanoma patients. Clinical findings were retrospectively evaluated. For histopathological parameters, HE sections were reexamined. The differentiation between de novo and nevus-associated melanoma was based on the ...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Lentigo maligna has an extensive and neoplastic character. It typically progresses slowly and may eventually develop into an invasive melanoma, which is called lentigo maligna melanoma. Ocular melanoma is the second most common type of melanoma. The uvea is the most common site of origin of ocular melanomas, while conjunctival melanoma accounts for about 1-5% of cases. In this article, we descr...

People with skin of color are more likely to have advanced melanomas at diagnosis, strikingly lower 5-year melanoma survival rates among Black (70%) compared white patients (92%). Yet, survey data suggests many people not been provided health information about cancer. We sought explore people’s perspectives on risk using in-depth qualitative interviewing. conducted 26 semi-structured interviews...

The incidence of cutaneous melanoma is increasing worldwide, especially for thin melanoma (Breslow ≤1 mm). Thin cutaneous melanoma has a favorable prognosis but there are few data about the prognosis of patients with ultra-thin cutaneous melanoma (Breslow ≤ 0.5 mm). Our aim was to investigate the disease-free survival among patients with invasive cutaneous melanoma with Breslow ≤ 0.5 mm after 1...

background and purpose: different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. unfortunately they don't always have desirable results and they may have unfavorable side effects. researchers try to find new, more effective drugs with low side effects. in this study we evaluated the cytotoxic effect of aca-1...

Malignant melanoma is an important healthcare issue. The incidence of melanoma has in‐ creased dramatically during the last few decades and melanoma is now one of the most com‐ mon forms of cancer. This aggressive form of skin cancer is characterized by its high capacity for invasion and metastasis. Patients with advanced stages of the disease have universally poor prognoses with a median survi...

Skin cancer is one of the most common cancers. Melanoma accounts for less than 2% of skin cancer cases but causes a large majority of skin cancer deaths. Early detection of malignant melanoma remains the key factor in saving lives. However, the melanoma diagnosis is still clinically challenging. Here, we developed a confocal photothermal microscope for noninvasive, label-free, three-dimensional...

Acral melanoma has been reported to have distinctive clinical presentation and ethnic distribution compared to other histological types of malignant melanoma. Acral melanoma also exhibits distinctive focused gene amplifications, including cyclin D1 overexpression. We reviewed archived histological material of malignant melanoma in the Sarawak General Hospital from year 2004 to 2010. 43 tumours,...

IMPORTANCE The risk of next melanoma in patients with 2 or more previous melanomas stratified by familial and sporadic cases separately has not yet been reported, although a few population-based studies have assessed the risk of second melanoma. OBJECTIVE To assess the risk of next melanoma in patients with multiple primary melanomas by number of previous melanomas, stratified by demographic ...