gliomas account for almost 80% of primary malignant brain tumors in adults. magnetic resonance imaging (mri) is still the gold standard for diagnosis of brain tumors and brain 99mtc-tetrofosmin single photon emission computed tomography (99mtc-tetrofosmin-spect) has been established as a useful tool for their evaluation. fluorine-18–2-fluoro-2-deoxy-d-glucose positron emission tomography/comput...

b-cell lymphoblastic lymphoma (b-lbl) is an uncommon subtype of pediatric non-hodgkin lymphoma (nhl) which rarely involves the skin primarily. the positron emission tomography with 2-deoxy-2-[fluorine- 18] fluoro-d: -glucose integrated with computed tomography (18f-fdg pet/ct) scan findings of a 8-year-old boy with cutaneous b-lbl were presented. pet/ct scan demonstrated mild fdg uptake in the ...

The title acesulfamate complex, [Pd(C(30)H(22)FO(2)P(2))(C(4)H(4)NO(4)S)], contains a four-coordinate Pd(II) ion with the expected, although relatively distorted, square-planar geometry where the four L-Pd-L angles range from 79.58 (8) to 102.47 (7)°. The acesulfamate ligand is N-bound to Pd [Pd-N = 2.127 (2) Å] with a dihedral angle of 76.35 (6)° relative to the square plane. Relatively long p...

Hsp70 chaperones mediate folding of proteins and prevent their misfolding and aggregation. We report here on a new kind of Hsp70 interacting protein in mitochondria, Hep1. Hep1 is a highly conserved protein present in virtually all eukaryotes. Deletion of HEP1 results in a severe growth defect. Cells lacking Hep1 are deficient in processes that need the function of mitochondrial Hsp70s, such as...

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It is a pleasure to be able to introduce this second Thematic Series on ‘organo-fluorine chemistry’ within the Beilstein Journal of Organic Chemistry. The series now embeds the subject firmly as a special interest area of the journal. The first series in 2008 presented contributions representing a wide range of organic fluorine chemistry [1-10] and this series continues that trend exploring the...

Objective(s): We performed a phase IIa clinical trial of trans-1-amino-3-18Ffluoro-cyclobutane carboxylic acid (anti-18F-FACBC), a synthetic amino acid analog for PET, in patients with metastatic prostate cancer. Methods: The study subjects consisted of 10 untreated prostate cancer patients having lymph node and/or bone metastasis. Five patients underwent whole-body PET 5 and 30 min after intra...

UNLABELLED Osteomyelitis complicates up to one third of diabetic foot infections, is often due to direct contamination from a soft-tissue lesion, and represents a clinical challenge. Early diagnosis is important since antibiotic therapy can be curative and may prevent amputation. The present study assessed the role of PET/CT using 18F-FDG for the diagnosis of diabetic foot osteomyelitis. METH...

Vacancies play a pivotal role in affecting ferroelectric polarization and switching properties, and there is a possibility that ferroelectricity may be utterly eliminated when defects render the system metallic. However, sufficient quantitative understandings of the subject have been lacking for decades due to the fact that vacancies in ferroelectrics are often charged and polarization in charg...