BACKGROUND Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation and is classified into types I, II and III based on structural changes in the glomerular capillary walls. The drusen-like deposits of MPGN type II have been studied, but the fundus changes in MPGN type III have yet to be clarified. We report a case of MPGN type III with multiple deposits ...

Purpose Mutations in membrane frizzled-related protein (MFRP) are associated with nanophthalmia, hyperopia, foveoschisis, irregular patches of RPE atrophy, and optic disc drusen in humans. Mouse mfrp mutants show retinal degeneration but no change in eye size or refractive state. The goal of this work was to generate zebrafish mutants to investigate the loss of Mfrp on eye size and refractive s...

Visual processing is thought to involve initial local analyses that are subsequently integrated globally to derive functional representations of structure that extends over large areas of visual space. Amblyopia is a common deficit in spatial vision that could be based on either unreliable local estimates of image structure, irregularities in global image integration or a combination of errors ...

We have asked how sensory adaptation is represented in the response of a population of visual motion neurons and whether the neural adaptation could drive behavioral adaptation. Our approach was to evaluate the effects of about 10 s of motion adaptation on both smooth-pursuit eye movements and the responses of neuron populations in extrastriate middle temporal visual area (MT) in awake monkeys....

Brain representations of visual space are predominantly eye-centred (retinotopic) yet our experience of the world is largely world-centred (spatiotopic). A long-standing question is how the brain creates continuity between these reference frames across successive eye movements (saccades). Here we use functional magnetic resonance imaging (fMRI) to address whether spatially specific repetition s...

OBJECTIVE To examine the phenomenon of a prolonged choroidal filling phase (PCFP) as seen on fluorescein and indocyanine green (ICG) angiography in patients with early age-related macular disease (AMD). METHODS One hundred eyes of consecutive patients with early AMD were studied. Patchy and slow choroidal filling in early fluorescein and distinct areas of reduced choroidal fluorescence in ICG...

Extra-retinal information about eye velocity is thought to play an important role in compensating the retinal motion experienced during an eye movement. Evidently this compensation process is prone to error, since stimulus properties such as contrast and spatial frequency have marked effect on perceived motion with respect to the head. Here we investigate the suggestion, that 'optokinetic poten...

To determine whether there is a critical period for development of eye-specific layers in the lateral geniculate nucleus (LGN), we prevented the normal segregation of retinogeniculate afferents and then allowed an extended period of time for recovery. After recovery, both anatomy and physiology revealed strictly nonoverlapping territories of input from the two eyes. However, the normal stereoty...

A 69 years gentleman, a non-diabetic with history of CAD, came to our OPD with complaints of altered sensation in the left supraorbital region, which he noticed while washing his face in the morning. Clinical examination revealed decreased sensations to fine touch, pain and temperature over left supraorbital region, improper eye closure on the left side, and strangely, absence of forehead wrink...

The squirrel monkey is the only primate reported to lack ocular dominance columns. Nothing anomalous about the visual capacity of squirrel monkeys has been found to explain their missing columns, leading to the suggestion that ocular dominance columns might be "an epiphenomenon, not serving any purpose" (Livingstone et al., 1995). Puzzled by the apparent lack of ocular dominance columns in squi...