The efficacy of novel cancer therapeutics can be hampered by inefficient delivery of agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have been shown to increase drug delivery to tumors. This study investigates the effects of a range of temperatures (34-42 degrees C) and hyperthermia tre...

Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through the bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding the extravasation process or re-entry of circulating tumor cells at metastatic sites. Here, we show that neuropilin-2 (NRP-2), a multifunctional n...

Vasopressors are an integral component of the management of septic shock and are traditionally given via a central venous catheter (CVC) due to the risk of tissue injury and necrosis if extravasated. However, the need for a CVC for the management of septic shock has been questioned, and the risk of extravasation and incidence of severe injury when vasopressors are given via a peripheral venous ...

Circulating tumor cells (CTCs) are the principal vehicle for the spread of non-hematologic cancer disease from a primary tumor, involving extravasation of CTCs across blood vessel walls, to form secondary tumors in remote organs. Herein, a polydimethylsiloxane-based microfluidic system is developed and characterized for in vitro systematic studies of organ-specific extravasation of CTCs. The sy...

In situ simulation is thought to offer a good learning environment due the fact that it carried out in real clinical practice. This study was performed compare effect of and simulated immersion on cancer nursing students extravasation management. The with randomized controlled pretest-posttest comparative design. participants were randomly assigned either group (n=19) or (n=24). data collected ...

Context: One of the common procedures in neonatal intensive care unit (NICU) is insertion a venous catheter, and one most important serious complications extravasation, which leading cause death hospitalized infants. Based on researcher’s experience NICU necessity extravasation injury management infants, this review study focused Methods: The literature was searched ProQuest, Scopus, PubMed dat...