now accepted that Paget’s disease may run in families, though uncommonly. The family with Paget’s disease reported here consists of a father and two daughters. The father’s case is of interest because of the rare type of malignant change which led to his death, and the affection in the two daughters is notable for the unusually early onset at eighteen years. There are three other siblings, two ...

Paget disease uncommonly affects the hand. When it does, radiographic findings are same as when the disease occurs elsewhere. Eleven new cases that demonstrate four predominant radiographic patterns are described: homogeneous sclerosis, trabecular coarsening, cortical thickening, and lysis. The homogeneous sclerosis pattern was associated with monostotic hand disease. One patient developed bila...

A brief review is given of the use of fluoride, mithramycin, glucagon, actinomycin D, calcitonins and diphosphonates for treatment of Paget's disease of bone. The decision regarding treatment, effectiveness of the drugs, the incidence of side effects and assessment of clinical, biochemical, histological, radiological and thermographic responses are discussed.

This article describes the structural and emotional disturbances in families with one or more members affected by Huntington's disease, according to the different symptoms, the affected member (offspring, parent) and the different stages of the disease. We consider that support services to the family should be made up of professionals who are specialists in the specific needs of the disease and...

Understanding of the pathogenesis, clinical course, and treatment of Raynaud's disease is confused and unsatisfactory, and no success in treatment can be promised. Five patients with severe Raynaud's disease, who had not responded to other forms of treatment, were treated by plasmapheresis, which produced a striking improvement. Ultrasonic velocimetry showed that segments of digital arteries wh...

The histopatholgic examination usually depends on the tissue section stained with Hematoxylin-eosin (H.E.). skin tissue’s view shows a saggital picture, including epidermis, dermis, and subcutaneous adipose in slice at glance. It is good to see structure of sagittal view, but it also hard horizontal structures. We recently established new fluorescent microscopy technique using transparency-enha...