glycoconjugates and their programmed changes during the course of development in the cell-surface as well as in the extracellular matrix, are known to affect cell differentiation, cellular interaction and other developmental phenomena during embryogenesis. the purpose of this study was to localize n-acetylgalactosamin as well as fucose-containing glycoconjugates in situ during thymus developmen...

conclusions we found a marked increase in the incidence of non-albicans species (48.2%) among neutropenic patients. only a few strains failed to produce extracellular enzymes. finally, in addition to fluconazole, caspofungin can be considered as the first line treatment against candida species among neutropenic patients. results a total of 110 yeast strains isolated from urine and oral cavities...

background and purpose: microorganism-based synthesis of nanostructures has recently been noted as a green method for the sustainable development of nanotechnology. nowadays, there have been numerous studies on the emerging resistant pathogenic bacteria and fungal isolates, the probable inability of bacteria and fungi to develop resistance against silver nanoparticles’ (snps) antibacterial, ant...

GABA receptors of bipolar cells from the skate retina: actions of zinc on GABA-mediated membrane currents. J. Neurophysiol. 78: 2402-2412, 1997. gamma-Aminobutyric acid (GABA)-induced currents were recorded from isolated bipolar cells of the skate retina using perforated patch-clamp methodology. Pharmacological analysis of the responses, using selective agonists and antagonists of the major cla...

The basal levels of extracellular Zn2+ are in the range of low nanomolar concentrations and less attention has been paid to Zn2+, compared to Ca2+, for synaptic activity. However, extracellular Zn2+ is necessary for synaptic activity. The basal levels of extracellular zinc are age-dependently increased in the rat hippocampus, implying that the basal levels of extracellular Zn2+ are also increas...

Introduction: During its life cycle, malaria parasite has to traverse successfully through widely diverse environmental milieu of mosquito mid gut, RBC cytosol and human circulatory system where it is exposed to dramatic changes of extracellular milieu in terms of pH, osmolarity and ionic constituents. Therefore, the aim of this study was to examine the possible changes in the cations (Na+, K+,...

S100A8/A9 (calprotectin), which is released by neutrophils under inflammatory conditions, has the capacity to induce apoptosis in various cells. We previously reported that S100A8/A9 induces apoptosis of EL-4 lymphoma cells via the uptake of extracellular zinc in a manner similar to DTPA, a membrane-impermeable zinc chelator. In this study, S100A8/A9-induced apoptosis was examined in several ce...

Matrix metalloproteinases (MMPs) are a family of zinc dependent extracellular matrix (ECM) remodelling endopeptidases having the ability to degrade almost all components of extracellular matrix and implicated in various physiological as well as pathological processes. Carcinogenesis is a multistage process in which alteration of the microenvironment is required for conversion of normal tissue t...

17B-Hydroxy-5a-androstan-3-one (dihydrotestosterone) may be the active androgen required for maintenance of many androgen-dependent tissues (King & Mainwaring, 1974). In the human prostate gland, testosterone is converted into dihydrotestosterone by aNADPH-dependent A4-3-oxosteroid 5a-oxidoreductase (5a-reductase) (Ofner et al., 1970). This enzyme has been located in both nuclear and microsomal...

results migration of cells started on the fifth day. as a result of this migration, most cells were located on the surface of the scaffold and formed epiderm-like structure and some penetrated into the scaffold. by day 25, cells which had penetrated into the scaffold had various destinies such as becoming elongated spindle-shaped cells and creating blood vessel-like structures. conclusions adm ...