BACKGROUND The pathophysiology of white matter involvement in dentatorubropallidoluysian atrophy (DRPLA) is controversial. Moreover, the clinical repercussions and evolution of these lesions have not been well documented. OBJECTIVE To describe a case of DRPLA with severe cerebellar white matter involvement. DESIGN Case report. Patient A 62-year-old woman with DRPLA. RESULTS When the genet...

Both the promise and the challenge of distributed systems often derive from emergent behavior, functionality that is not defined explicitly in the individual components of the system but results from their interactions. Effective use of these systems depends on techniques for monitoring and controlling such system-level behavior. A fruitful source of inspiration for such techniques is statistic...

We discuss several aspects of astroparticle physics pertaining to a new model with MeV cold dark matter particles, which annihilate to electron-positron pairs in a manner yielding the correct CDM density required today, and explaining the enhanced electron-positron annihilation line from the center of the Galaxy. We note that the mass of the vector meson mediating the annihilations, should exce...

Many recent researches have investigated the deviations from Friedmannian cosmological model, as well their consequences on unexplained phenomena, such dark matter and acceleration of Universe. On one hand, a first-order perturbative study inhomogeneity returned partial explanation energy, relativistic effects due to retarded potentials far objects. other fractal cosmology, now approximated by ...

Milgrom has proposed that the appearance of discrepancies between the Newtonian dynamical mass and the directly observable mass in astronomical systems could be due to a breakdown of Newtonian dynamics in the limit of low accelerations rather than the presence of unseen matter. Milgrom’s hypothesis, modified Newtonian dynamics or MOND , has been remarkably successful in explaining systematic pr...