The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected biomarkers were assessed in control group, dyspnea group, and HF group. On exercise dyspnea patients had lower early diastolic (E') and systolic (S') mitral annular velocity ...

BACKGROUND Exertional dyspnea is a hallmark symptom of fibrosing interstitial lung disease (fILD), and oxygen (O2) desaturation is common among patients with fILD. Supplemental O2 is prescribed to maintain normoxia and alleviate dyspnea. We sought to better understand the associations between O2 and dyspnea in fILD during the 6-min walk test (6MWT). METHODS 1326 fILD patients compose the samp...

Dyspnea is a common problem among patients with interstitial fibrosis, lung cancer, cystic fibrosis, and chronic obstructive pulmonary disease. The slow but steady progression of such diseases, often punctuated by acute exacerbations or secondary illnesses, can lead to decision-making dilemmas among patients and their caregivers, such as when to accept mechanical ventilation, when to forgoe agg...

Elevated endorphin levels in patients with COPD may act to diminish the sensation of dyspnea. Exogenous opioids decrease exertional dyspnea and increase exercise capacity in COPD patients. The purpose of this study was to determine the effects of endogenous opioids on the exercise capacity and control of breathing in patients with COPD. We hypothesized that naloxone, an opioid antagonist, would...

R.D. (JHH no. A 511024), a 26-year-old wh te man, who, although cyanotic at birth, was acyanotic during early childhood, grewv and developed well and only suffered mild to moderate exertional dyspnea. At 7 years of age, cyanosis reappeared, squatting became apparent, and the dyspnea and fatigability increased. In spite of these sympitoms the patient finished high school and was able to perform ...

A 36-year-old male presented with progressive exertional dyspnea over months. Physical examination showed jugular venous distension, lung crecipitations, femoral bruit and pitting pedal edema. Echocardiogram showed a dilated right ventricle with severe pulmonary hypertension and a non collapsing inferior vena cava (IVC). On right heart catheterization, IVC oxygen saturation was noted at 92% sug...

A 41-year-old man was referred to the outpatient clinic of our respiratory care department presenting with the symptoms of progressive cough, exertional dyspnea and tachycardia. The symptoms had started about 18 months earlier and had worsened continuously during the past year. At presentation the patient complained of dyspnea at the slightest exertion. An external chest radiograph showed shado...