introduction: previous studies indicate that exercise influences cognitive function. nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. the present study aimed to investigate the effects of treadmill exercise on ltp in the dentate gyrus of rats. methods: th...

introduction: exercise training increases skeletal muscle capillary density, but the molecular mechanisms of this process are not yet clear. the aim of the present study was to investigate the effect of acute long- term submaximal exercise on serum vascular endothelial growth factor (vegf) as the main angiogenic factor, and matrix metalloproteinases 2 and 9 ( mmp-2 and mmp-9), as the degrading ...

conclusions there were significant distinctions in the skin temperature distribution during exercise according to the activity of the area under consideration during exercise, which may be important in the development of physiological models and heat flux analyses for different purposes. results during pre-exercise, all tsk reached a steady-state (p ≤ 0.05), which ensured adequate thermal stabi...

the aim of the present study was to investigate the effect of two programs of standard sets and circuit weight training with different intensities on response of excess post exercise oxygen consumption (epoc) in young men. for this purpose, twelve healthy men (mean±sd: age, 21.92±1.1 years; height, 175.17±4.55cm; weight, 69.74±7.5kg) were voluntarily selected and participated in two stages of t...

it is generally believed that unaccustomed exercise causes myofibrillar damage. in recent years, cold water immersion (cwi) following heavy training sessions and matches has been common aiming at reducing soreness. however, there is no strong scientific rationality if this method really accelerates recovery after exercise. in addition, there is a question that if it is possible for this method ...

objective(s): the purpose of this study was to investigate effects of short-term aerobic exercise on energy intake, appetite and energy-regulating hormones in free-living men and women.   materials and methods: sixteen (eight men, eight women) sedentary young normal weight subjects participated in two experimental conditions with two days apart: five days control with no exercise, and five days...

some important compatibility that occur with exercise is increase of the capillary density or angiogenesis. vascular endothelial growth factor (vegf) have mitogen role for endothelial cells and consider an important intermediary angiogenesis process. the purpose of this study was comparing the effect of two type of physical activity on response of serum vegf-a in non-athlete men. for this aim 1...

In order to achieve prolong corneal contact time of norfloxacin (NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in-situ gelling system was designed to explore dual advantage of nanoparticles and in-situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-li...

4. Tetrahydropteroylglutamate is a competitive inhibitor of the cofactor activity of extract of heated E. coli, and of tetrahydropteroyltriglutamate and its N5-formyl derivative. It also inhibits the activity of the N10-formyl compound. In all cases the inhibition is overcome by the addition of cobalamin. 5. The cofactor activity of tetrahydropteroylglutamate and tetrahydropteroyltriglutamate i...

2-Deamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) is a potent inhibitor of thymidylate synthase. Its analogue, N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid, containing p-aminophenylacetic acid residue substituting p-aminobenzoic acid residue, was synthesized. The new analogue exhibited a moderately potent thy...