The translocation liposarcoma protein TLS has recently been shown to function as an adapter molecule coupling gene transcription to RNA splicing. Here we demonstrate that YB-1, a protein known to play important roles in transcription and translation, interacts with the COOH-terminal domains of TLS and the structurally related Ewing's sarcoma protein EWS. Through this interaction, YB-1 is recrui...

BACKGROUND The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/beta-catenin signaling and has a crucial role in development. Recent studies have revealed the involvement of this family in tumorigenesis, however their role in tumorigenesis is still remained unclear. METHODOLOGY/PRINCIPAL FINDINGS We found increased expression of DKK2 but decreased expressio...

Ewing sarcoma (EWS) proto-oncoprotein, an RNA-binding protein, is involved in DNA recombination and repair, gene expression, RNA processing and transport, as well as cell signalling. Chimeric EWS oncoproteins generated by chromosomal translocations between EWSR1 and the genes of transcription factors cause malignant tumors. To understand the loss of function by these translocations, the role of...

Background: Endobronchial embolization is an alternative strategy for the management of pneumothorax or empyema with persistent air leakage. The previous reports analyzed heterogeneous populations of patients, including patients with good performance status (PS, 0 or 1). However, the usefulness of Endobronchial embolization for managing persistent air leakage in patients with poor PS (3 or 4) i...

In Ewing sarcoma, NKX2-2 is a critical activated target of the oncogenic transcription factor EWS/FLI that is required for transformation. However, its biological function in this malignancy is unknown. Here we provide evidence that NKX2-2 mediates the EWS/FLI-controlled block of mesenchymal features. Transcriptome-wide RNA sequencing revealed that NKX2-2 represses cell adhesion and extracellul...

An Early Warning System or EWS is a core type of data driven IoT (Internet of Things) system used for environment disaster risk and effect management. The potential benefits of using a semantic type EWS include easier sensor and data source plug-and-play, simpler, richer and more dynamic metadatadriven data analysis and easier service interoperability and orchestration. The challenges faced dur...

BACKGROUND Chromosomal translocations generating oncogenic transcription factors are the hallmark of a variety of tumors, including many sarcomas. Ewing sarcoma family of tumors (ESFTs) are characterized by the t(11;22)(q24;q12) translocation that generates the Ewing sarcoma breakpoint region 1 and Friend leukemia virus integration 1 (EWS-FLI1) fusion transcription factor responsible for the hi...

Entanglement in symmetric quantum states and the theory of copositive matrices are intimately related concepts. For simplest states, i.e., diagonal (DS) it has been shown that there exists a correspondence between exceptional (non-exceptional) non-decomposable (decomposable) Witnesses (EWs). Here we show EWs symmetric, but not DS, can also be constructed from extended matrices, providing new ex...

In more than 95% of patients, the Ewing family of tumors (ET) has chimeric transcripts caused by fusion of the EWS gene to either FLI1 or ERG. The presence of specific EWS-FLI1 or EWS-ERG transcripts in peripheral blood (PB) samples of patients being treated for ET was prospectively evaluated, and these data were correlated to their clinical status. The authors studied 113 PB samples from 28 pa...

The adenovirus 5 early region 1A (E1A) can function as a tumor suppressor gene and is being used in clinical trials as a therapeutic agent for advanced breast, ovarian, and head and neck cancer. Recently, there has been a dispute regarding whether transfection with the E1A gene can induce expression of the Ewing sarcoma oncogenic fusion transcript EWS-FLI1 (Sanchez-Prieto et al., Nat. Med., 5: ...