نتایج جستجو برای: ewing

تعداد نتایج: 2735  

Journal: :American Journal of Public Health 1981

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Fernanda I Arnaldez Lee J Helman

Ewing sarcoma is the second most common pediatric malignant bone tumor. Aggressive multimodality therapy has led to an improvement in outcomes, particularly in patients with localized disease. However, therapy-related toxicities are not trivial, and the prognosis for patients with relapsed and/or metastatic disease continues to be poor. In this article, we outline some of the promising therapie...

2011
Lars Wagner

New therapies are needed to improve survival for patients with Ewing sarcoma. Over the past decade, camptothecin agents such as topotecan and irinotecan have demonstrated activity against Ewing sarcoma, especially in combination with alkylating agents. Previous studies have shown camptothecin-based combinations to be tolerable outpatient strategies that are attractive for salvage therapy. This ...

2013
Yijun Zhou Zheng Tian Akbar Yunus Jiangtao Chen Chong Wang Leilei Xu Xinghua Song

The Clavicle is a rare primary site for Ewing sarcoma (ES). We report one case of patient with clavicular ES under our tracking and review the related literatures on management of this rare tumor. The patient was age of 35 years and was non metastatic at presentation. The patient received chemotherapy before and after the surgery. Claviculectomy was used. The patient had good functional outcome...

2010
Serhat Avcu Hüseyin Akdeniz Aydın Bora Harun Arslan

We report the ultrasonography (US) and computed tomography (CT) findings of a rare case of extraskeletal Ewing sarcoma involving the left chest wall with a diameter of 4cm in a 5 years old girl. The lesion was heterogenously hypoechoic on sonography with a lobulated smooth contour. On CT, the lesion had central necrotic areas and was enhancing heterogeneously. With these US and CT findings surg...

Journal: :PLoS Medicine 2007
Kimberly Stegmaier Jenny S Wong Kenneth N Ross Kwan T Chow David Peck Renee D Wright Stephen L Lessnick Andrew L Kung Todd R Golub

BACKGROUND The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conventional small-molecule screening. Despite the identification of tumor-specific somatic mutations, most cancer therapy still utilizes no...

2017
Yong-Jiang Li Xi Yang Wen-Biao Zhang Cheng Yi Feng Wang Ping Li

Cancer-related systemic inflammation responses have been correlated with cancer development and progression. The prognostic significance of several inflammatory indicators, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), C-reactive protein to albumin ratio (CRP/Alb ratio), lymphocyte-monocyte ratio (LMR), and neutrophil-platelet scor...

2015
Malcolm A. Smith C. Patrick Reynolds Min H. Kang E. Anders Kolb Richard Gorlick Hernan Carol Richard B. Lock Stephen T. Keir John M. Maris Catherine A. Billups Dmitry Lyalin Raushan T. Kurmasheva Peter J. Houghton

Background: Inhibitors of PARP, an enzyme involved in base excision repair, have demonstrated single-agent activity against tumors deficient in homologous repair processes. Ewing sarcoma cells are also sensitive to PARP inhibitors, although the mechanism is not understood. Here, we evaluated the stereoselective PARP inhibitor, talazoparib (BMN 673), combined with temozolomide or topotecan. Proc...

Journal: :Clinical and experimental rheumatology 2006
S Schwemmer P Beer J Schölmerich M Fleck R H Straub

OBJECTIVES Patients with inflammatory diseases often demonstrate autonomic nervous dysfunction. This study was initiated to investigate cardiovascular (CAD) or pupillary autonomic dysfunction (PAD) in patients with rheumatoid arthritis (RA). METHODS Between 1997 and 1998, 33 RA patients were examined for characteristics, and parameters of CAD and PAD. In a longitudinal part of this study, thi...

2017
Stefanie de Groot Hans Gelderblom Marta Fiocco Judith VMG Bovée Jacobus JM van der Hoeven Hanno Pijl Judith R Kroep

BACKGROUND Activation of the insulin-like growth factor 1 (IGF-1) pathway is involved in cell growth and proliferation and is associated with tumorigenesis, tumor progression, and therapy resistance in solid tumors. We examined whether variability in serum levels of IGF-1, IGF-2, and IGF-binding protein 3 (IGF-BP3) can predict event-free survival (EFS) and overall survival (OS) in Ewing sarcoma...

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