Accepted September 16, 2013 Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work was to develop modified in situ gelling alginate formulations capable of sustaining dextromethorpha...

queous film-coating processes can influence many quality aspects of the final coated product, including coated-tablet moisture content, surface roughness, gloss, coating efficiency, and coating uniformity. Colorcon’s aqueous tablet-coating formulations must be capable of meeting these and other customer requirements in different application environments around the world using various types of c...

Terapi farmakologi lini pertama pada pasien diabetes melitus terutama tipe II obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan banyak kelemahan seperti menimbulkan efek samping rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi diperpanjang (extended release). Tujuan penulisan review ar...

Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work was to develop modified in situ gelling alginate formulations capable of sustaining dextromethorphan release throughout the gas...

The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach which oral dispersible tablet. Oral tablet also called as mouth dissolving tablet, fast or disintegrating has advantage it quickly disintegrates into saliva when put on the tongue. faster drug dissolved, absorption and quicker therapeutic effect of will be attained. objec...

The purpose of this study was to investigate coating process of tablets with the novel starch hydrolysate emulsion. The process was performed manually in a coating pan rotating 35 rpm, with a stream of dry air (40 - 45 degrees C). The coated tablets were of fairly good quality. A total tablet surface was calculated for evaluation of quantity of starch hydrolysate emulsion for one step of coatin...

DESCRIPTION ISOPTIN SR (verapamil hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). ISOPTIN SR is available for oral administration as light green, capsule shaped, scored, film-coated tablets containing 240 mg verapamil hydrochloride, as light pink, oval shaped, scored, film-coated tablets containing 180 mg verapamil hydrochloride, and as light v...

blood pressure rises rapidly upon awakening and maybe responsible, in part, for the increased incidence of myocardial infarction and stroke during the morning hours. the aim of the present study was, therefore, to develop a novel chronotherapeutic formulation of metoprolol tartrate (mt) for night time dosing providing maximum effect in the morning hours. core tablets contained mt, sodium chlori...

Divalproex sodium Chemically it is designated as sodium hydrogen bis(2-propylpentanoate) is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. Divalproex sodium is an anticonvulsant drug. Increase level of gama-amino butyric acid in brai...