conclusions ia fluid resuscitation is superior to iv resuscitation in hemorrhagic shock induced cardiac arrest. results while iv rl infusion failed to restore chest motion in mice (n = 5), ia rl infusion restored chest motion in all mice examined (n = 6) (p = 0.0067). in three mice, iv rl infusion after cardiac arrest showed no effect on cc. after failure of venous infusion, ia rl infusion was ...

In order to assess the influence of breed on the vertebral heart scale (VHS) of dogs, the VHS was measured and compared in left to right (LL) and right to left lateral (RL) views. For all dogs (n=56), the mean VHS on the RL radiographs [9.7 vertebra (v)] was significantly larger than the mean VHS on the LL radiographs (9.6 v) (p=0.047). Doberman dogs had higher mean values of the VHS in LL (9.9...

A novel experimental pHand time-dependent colonic drug delivery system was prepared and its in vitro and in vivo performances were evaluated. The colonic delivery system consists of minitablets with a big swelling capacity coated with an inlet retardant layer insoluble at all pH ranges but permeable (Eudragit RS 30D) and an outlet layer, insoluble and impermeable at acidic pH but easily soluble...

This research focuses on the development of enteric microparticles of lansoprazole in a single step by employing the spray drying technique and studies the effects of variegated formulation/process variables on entrapment efficiency and in vitro gastric resistance. Preliminary trials were undertaken to optimize the type of Eudragit and its various levels. Further trials included the incorporati...

Background Glaucoma is a serious eye disease that can lead to loss of vision. Unfortunately, effective treatments are limited by poor bioavailability of antiglaucoma medicine due to short residence time on the preocular surface. Materials and methods To solve this, we successfully prepared novel controlled-release ion-exchange microparticles to deliver betaxolol hydrochloride (BH). Montmorill...

BACKGROUND Gemcitabine is an analogue of deoxycytidine with activity against several solid tumors. In order to elucidate the mechanisms by which tumor cells become resistant to gemcitabine, we developed the resistant subline RL-G from the human follicular lymphoma cell line RL-7 by prolonged exposure of parental cells to increasing concentrations of gemcitabine. RESULTS In vitro, the IC50 inc...