The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The mic...

Since decade or two, the development of floating drug delivery systems becomes a significant and novel tool as having low density than gastric content. There are various advanced polymers including chitosan, eudragit, etc., and excipients such as; pore forming agent, surfactants, etc. All of them are discussed briefly, and results are concluded from various reputed researches. We have discussed...

Whispering gallery mode resonators (WGMR) are an efficient tool for the realization of optical biosensors. A high Q factor preservation is a crucial requirement for good biosensor performances. In this work we present an Eudragit®L100 coated microspherical WGMR as an efficient immunosensor. The developed resonator was morphologically characterized using fluorescence microscopy. The functionaliz...

Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media pH. Methods: Different formulations slow-release matrix tablets were polymers, namely, ethyl cellulose (Etc), hydroxyethyl (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using embedding technique. The characterized studies their prof...

Results: Drug-Eudragit granules E3 prepared by mass extrusion method gave less than 10% of drug in simulated saliva fluid and almost complete release in simulated gastric fluid after 2 minutes. Therefore, it was used to prepare oro-dispersible tablets formulas. In vitro disintegration time of formula T2 was 45.5 ± 7.7 seconds showed a complete drug release of Prifinium Bromide in phosphate buff...

in this study, the effects of various hydrophilic (hpmc and carbopol 971) and plastic (ethylcellulose and eudragit rl100) polymers on the release profile of diltiazem hcl from matrix tablets were evaluated in-vitro. for this purpose, tablets containing 60 mg of diltiazem hcl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. tablets prep...

An effective delivery vehicle of genetic materials to their target site is the key a successful gene therapy. In many cases, nanoparticles are used as choice and efficiency relies heavily on physicochemical properties nanoparticles. Microfluidics, although being low throughput method, has been increasingly researched for preparation A range superior were claimed in literature microfluidic-prepa...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

An oral colon delivery platform based on a novel combination strategy, leveraging multiple physiological characteristics of the intestine, is proposed. The system comprises drug core, water-swellable/soluble inner layer hydrophilic cellulose derivative and an enteric outer (Eudragit® S) containing microbially-degradable polysaccharide (high-amylose starch, Amylo N460), acting synergistically to...