The reaction of cyclopentanone with cyanoacetylhydrazine gave 2-cyano-2-cyclopentylideneacetohydrazide (1). Treatment of compound 1 with elemental sulphur in the presence of triethylamine afforded 2-amino-5,6-dihydro- -4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which in-turn formed the corresponding intermediate diazonium salt. The latter was coupled with either ethyl cyanoacetate or ethyl...

In this study, TiO2 ceramic oxide film with good passivity, low conductivity and tribological properties was coated on stainless steel (AISI 304) material by sol gel spin coating method. The effect of annealing temperature time the structure films investigated. Ethyl acetoacetate (EAcAc), ethanol as titanium source Tetra-n-butyl orthotitanate (TBT) used for process. thin process, 2600 rpm chose...

Since the discovery by Knoevenagel [1] that doubly activated carbonic acids (CH-acids) react with carbonyl compounds to give the corresponding conjugated olefins, this reaction has been widely used in organic synthesis as an important method for carbon —carbon bond formation [2, 3). The conden­ sation of 1,3-dicarbonyl compounds with monocar­ bonyl compounds usually leads to a,/3-unsaturated pr...

Expedient asymmetric total syntheses of both (R)-podoblastin-S and (R)-lachnelluloic acid, representative of natural 3-acyl-5,6-dihydro-2H-pyran-2-ones, were performed. Compared with the reported total synthesis of (R)-podoblastin-S (14 steps, overall 5% yield), the present study was achieved in only five steps in an overall 40% yield and with 98% ee (HPLC analysis). In a similar strategy, the ...

The intestinal worm, Ascaris lumbricoides, ferments carbohydrate to a mixture of end products, of which the two major ones are Z-methylbutyrate and 2-methylvalerate. The mode of formation of branched chain acids with a methyl group at C-2 or other even numbered carbon atoms is still not completely understood. It has been proposed that these compounds could be formed either from the fatty acid s...

in recent years, the effects of heterogeneous catalysts for the oxidation of organic and inorganic pollutants in industrial wastewaters are spread. traditionally, these reactions are usually carried out using suspensions of photo-catalysts such as tio2. a chemical method including ticl4, al(no3)3, ethanol amine, ethyl acetoacetate and aqueous ammonia were used for the fabrication of tio2-al2o3 ...

To determine the temporal relationship between changes in contractile performance and flux through the citric acid cycle in hearts oxidizing acetoacetate, we perfused isolated working rat hearts with either glucose or acetoacetate (both 5 mM) and freeze-clamped the tissue at defined times. After 60 min of perfusion, hearts utilizing acetoacetate exhibited lower systolic and diastolic pressures ...

3-Amino-3-thioxopropanamide (1) reacted with ethyl acetoacetate to form 6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-carboxamide (2), which reacted with α-haloketones 3 to produce 2,3-disubstituted-8-hydroxy-6-methyl-2H,5H-pyrido[3,2-f]-[1,4]thiazepin-5-ones 4a-c. Benzoylation of 4c led to the formation of the dibenzoate derivative 9. Compounds 4a-c could be prepared stepwise through the f...