Public health interventions usually operate at the level of groups rather than individuals, and cluster randomized controlled trials (RCTs) are one means of evaluating their effectiveness. Using examples from six such trials in Bangladesh, India, Malawi and Nepal, we discuss our experience of the ethical issues that arise in their conduct. We set cluster RCTs in the broader context of public he...

Facebook’s experimental manipulation of newsfeed content and the subsequent PNAS publication of significant findings from it (1) have drawn attention to the regulation of human participation in academic research and to the differences between commercial and academic research. Those events were recognized in an Expression of Concern in PNAS (2). In commerce and on the Internet, experimentation i...

This article analyzes the religio-ethical discussions of Muslim religious scholars, which took place in Europe specifically in the UK and the Netherlands, on organ donation. After introductory notes on fatwas (Islamic religious guidelines) relevant to biomedical ethics and the socio-political context in which discussions on organ donation took place, the article studies three specific fatwas is...

Background Multi-centre studies generally cost more than single-centre studies because of larger sample sizes and the need for multiple ethical approvals. Multi-centre studies include clinical trials, clinical quality registries, observational studies and implementation studies. We examined the costs of two large Australian multi-centre studies in obtaining ethical and site-specific approvals. ...

Seeking ethics committee approval for research can be challenging even for relatively simple studies occurring in single settings. Complicating factors such as multicentre studies and/or contentious research issues can challenge review processes, and conducting such studies internationally adds a further layer of complexity. This paper draws on the experiences of the LINNAEUS Collaboration, an ...

We propose novel hardware accelerator architectures for the most computationally demanding algorithms of the MPEG-4 video compression standard-motion estimation, binary motion estimation (for shape coding), and the forward/inverse discrete cosine transforms (incorporating shape adaptive modes). These accelerators have been designed using general low-energy design philosophies at the algorithmic...

In this paper, we analyze the various philosophies to define a query language for geographical database. The differences among the three possibilities of extending the SQL language rely on the definition of the clause Select: (1) the clause Select does not accept a spatial operator and the Where clause accepts one (or several) predicate defined between attributes; (2) the clause Select accepts ...

I think that an underappreciated factor in succeeding as a principal investigator is getting the lab’s internal culture right. For my lab, the goal is an environment that is highly collaborative, e.g., with open sharing and recombination of raw ideas into better ideas. We havemanaged to maintain a highly collegial, drama-free environment over these past 7 years, but as the lab has gotten bigger...