Naghashpour, M., and G. Dahl. Sensitivity of myometrium to CGRP varies during mouse estrous cycle and in response to progesterone. Am. J. Physiol. Cell Physiol. 278: C561–C569, 2000.—Calcitonin gene-related peptide (CGRP) inhibits contractions of the myometrium. Isometric force measurements on myometrial strips were carried out to monitor the inhibitory capacity of CGRP in the myometrium during...

Two experiments were conducted utilizing ewes to determine the effects of small diameter IUDs on fertility, lengths of estrous cycles and uterine histology. In both experiments, IUDs were inserted bilaterally at day 3 of the estrous cycle (estrus = day 0). The IUDs were single strands of nylon suture (.3 mm diameter) lying free in the uterine lumen except at a point of attachment near the utero...

Background: Active immunization with gonadotropin releasing hormone conjugate (GnRH-BSA) manipulates the fertility axis and thus alters the reproductive cyclicity, serum estradiol and progesterone levels. While the application of Kamdhenu ark increases the efficacy of GnRH-BSA. Objective: This experimental investigation is aimed to evaluate the modulatory effects on estrous cycle, serum estradi...

Two experiments were conducted to evaluate peripheral concentrations of cortisol (C), growth hormone (GH), and testosterone (T) in bulls and boars during mating and to correlate mating behaviors with endocrine secretion in the presence of an estrous female. In Exp. 1, six sexually inexperienced mature bulls were bled every 15 min for 2 h before and 2 h after a 30-min exposure to a single, restr...

A normal bovine estrous cycle contains 2 or 3 waves of follicle development, and ovulation takes place in the last wave. However, the biological mechanisms that determine whether a cycle has 2 or 3 waves have not been elucidated. In a previous paper, we described a mathematical model of the bovine estrous cycle that generates cyclical fluctuations of hormones, follicles, and corpora lutea in es...

OBJECTIVE Orexins have been implicated in the regulation of several physiological functions including reproduction, energy balance and vigilance state. For successful reproduction, the precisely timed hormonal secretions of the estrous cycle must be combined with appropriate nutritional and vigilance states. The steroid- and nutritional state-dependent modulation of LH release by orexins, as we...

During embryo implantation in pigs, the uterine endometrium undergoes dramatic morphological and functional changes accompanied with dynamic gene expression. Since the greatest amount of embryonic losses occur during this period, it is essential to understand the expression and function of genes in the uterine endometrium. Although many reports have studied gene expression in the uterine endome...

Molecular and intra-cellular mechanisms involved in the regulation of apoptosis processes in endometrial cells are poorly understood and documented. We have investigated the possibility that Akt survival pathway might be involved in the regulation of apoptosis in the uterus during the estrous cycle. Rats with regular estrous cycle (4 days) were killed at different days of estrous cycle (diestru...

Studies in cattle assessing changes in number and size of antral follicles, concentrations of estradiol, androgens and progesterone in serum and follicular fluid, and numbers of gonadotropin receptors per follicle during repetitive estrous cycles and postpartum anestrus are reviewed. The rate of growth of small follicles (1 to 3 mm) into larger follicles increases as the estrous cycle progresse...

The transcriptional factor OCT4 regulates pluripotency of stem cells and has an important role during oocyte growth. Whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. Therefore, this study was aimed to investigate the expression patterns of OCT4 in mouse ovaries during the normal estrous cycle. Adult National Medical Research Institute mice were classified as...