There exists many software applications that attempt to use common sense reasoning to assist users do everyday tasks, such as schedule their day or write emails. One such program is ARIA, which relies on the information in OpenMind’s common sense database. However, these applications are only as useful as the quality of the common sense information with which they are reasoning. One vast improv...

Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...

Multivesicular bodies (MVBs) are intracellular endosomal organelles characterized by multiple internal vesicles that are enclosed within a single outer membrane. MVBs were initially regarded as purely prelysosomal structures along the degradative endosomal pathway of internalized proteins. MVBs are now known to be involved in numerous endocytic and trafficking functions, including protein sorti...

Singapore is well known for its harsh stance against drug traffickers, with trafficking carrying some of the most severe penalties available in law. This includes mandatory death penalty where weight exceeds a statutory threshold. The act also broadly defined Misuse Drugs Act 1973 and can encompass wide range activities. In series authoritative decisions since 1994, this has included safekeepin...

OBJECTIVES To evaluate crack cocaine use practices, risk behaviors associated with HIV infection among drug users, and their involvement with violence. INTRODUCTION HIV infections are frequent among drug users due to risky sexual behavior. It is generally accepted that crack cocaine use is related to increased levels of violence. Several reports point to an increase in violence from those inv...

we call a module  essentially retractable if homr for all essential submodules n of m. for a right fbn ring r, it is shown that: (i)  a non-zero module  is retractable (in the sense that homr for all non-zero ) if and only if certain factor modules of m are essentially retractable nonsingular modules over r modulo their annihilators. (ii)  a non-zero module  is essentially retractable if and on...

OBJECTIVE Although there are many studies on risk factors for drug use, little has been known about the reasons that prevent people away from drug use. The aim of this study was to identify the reasons that would prevent low-income youngsters against psychotropic drug experimentation and use, even when living in a drug dealing environment. METHODS A qualitative study was carried out in an int...