The adipocyte-derived hormone leptin regulates appetite and bone mass. Recent research demonstrates that reciprocally, osteoblasts have a role in controlling energy metabolism. Several genes expressed in osteoblasts are involved in this process, and one of them is the Esp gene. The remaining genes regulate Esp gene expression. OST-PTP, the protein name of Esp, regulates the carboxylation of ost...

One of the challenging problems for surface mining operation optimization is choosing the optimal truck and loader fleet. This problem is the Equipment Selection Problem (ESP). In this paper, we describe the ESP in the context of surface mining. We discuss related problems and applications. Within the scope of both the ESP and related problems, we outline modeling and solution approaches. Using...

Bohun CM, Potts JE, Casey BM, Sandor GG. A population-based study of cardiac malformations and outcomes associated with dextrocardia. Am J Cardiol. 2007;100:305–9. Icardo JM, Garcia Rincon JM, Ros MA. Malformaciones cardı́acas, heterotaxia y lateralidad. Rev Esp Cardiol. 2002;55:962–74. Perloff JK. The cardiac malpositions. Am J Cardiol. 2011;108:1352–61. Palacios IF. Sustitución percutánea de v...

Electron microscopy can provide accurate, high-resolution images of the distribution of electrostatic potential (ESP) in biological macromolecules. Careful examination of ESP maps that have been published for peptides and proteins at resolution ranging from 1.0 Å to 2.9 Å reveals that the negative charges of carboxylate groups have a profound effect on their appearance. It is clear that investi...

Embedded scalable platforms (ESP) are a novel generation of platform architectures that yield optimal energy-performance operations while supporting a diversity of embedded application workloads. A companion methodology combines full-system simulation, pre-designed HW/SW interface libraries, high-level synthesis and FPGA prototyping to enable an effective design-space exploration which is drive...

The Clinton Administration has implied that short-run failures to control health care costs may cause a reexamination of wage and price controls as elements of comprehensive health care reform. The most recent imposition of mandatory wage and price controls was the Economic Stabilization Program (ESP) of the early 1970s. We analyze trends in hospitals' economic behavior and utilization before, ...

Evolutionary algorithms have been applied with great success to the difficult field of multi-objective optimisation. Nevertheless, the need for improvements in this field is still strong. We present a new evolutionary algorithm, ESP (the Evolution Strategy with Probabilistic mutation). ESP extends traditional evolution strategies in two principal ways: it applies mutation probabilistically in a...

Some measures of re l ig iosity, bel ief in an after l i fe , and bel ief in psychic phenomena were included in eight forced-choice ESP experiments. Seven of the experiments consisted of 40 trials of clairvoyance as a computer game and 40 trials of precognition in a paper-and-pencil test for each subject; and in one experiment there were 80 trials of clairvoyance. A combined measure of religios...