Background and purpose Many drugs can worsen myasthenia symptoms. The clinician usually relies on cautionary lists compiled according to case reports. We intended provide a quantitative basis for risk comparison within the groups of antiepileptic, antidepressant, neuroleptic, sedative drugs. Methods extracted adverse drug reaction (ADR) counts (total related) from these calculated reporting odd...

CONTEXT Recent observational studies have suggested that the use of selective serotonin reuptake inhibitors is associated with an increased fracture risk and an accelerated bone loss, although conflicting results have been reported. Furthermore, because many of these studies have been performed in depressed women, confounding by indication may influence these findings. OBJECTIVE The objective...

Escitalopram is a widely used antidepressant and antianxiety agent in clinical setup. This study was aimed at developing validating very sensitive specific bioanalytical method for the estimation of escitalopram rat plasma using liquid chromatography coupled with tandem mass spectrometry as per current United States Food Drug Administration (May 2018) guideline. The spectrometer operated heated...

this study was done to assess bioequivalence between test and reference formulations of escitalopram oxalate 20 mg in healthy indian male subjects. this single-dose, randomized, open-label, 2-period crossover study was carried out in 12 healthy indian male volunteers aged 18 to 55 years under fasting conditions with a wash out of 14 days.  the subjects were randomly assigned to receive the test...

Abstract Background Musical obsession has been reported as the “stuck song syndrome” and can be accompanied by obsessive compulsive disorder (OCD). is phenomenon where a particular set of known musical notes are perceived repeatedly. We present case major depression with obsession. In this case, vortioxetine improved both depressive symptoms Case presentation A female, 34-year-old, high school ...

OBJECTIVE Various studies have shown that short (s)/long (l) polymorphisms of the serotonin transporter-linked polymorphic region (5-HTTLPR) might predict treatment outcome to selective serotonin reuptake inhibitors. The purpose of this study was to evaluate the association between 5-HTTLPR and clinical response to escitalopram treatment in Korean subjects with major depressive disorder. METH...

BACKGROUND AND PURPOSE EEG studies show that 5-HT is involved in regulation of sleep-wake state and modulates cortical oscillations. Vortioxetine is a 5-HT3 , 5-HT7 , and 5-HT1D receptor antagonist, 5-HT1B partial agonist, 5-HT1A agonist, and 5-HT transporter inhibitor. Preclinical (animal) and clinical studies with vortioxetine show positive impact on cognitive metrics involving cortical funct...

BACKGROUND Anxiety and depression are common mental health disorders that are responsible for considerable societal burden. There are no data on cost-efficacy and medication compliance related to the treatment of these disorders in rural India. MATERIALS AND METHODS All consenting adults (n = 455) diagnosed with generalized anxiety or (unipolar) depressive disorders in Suttur village, Karnata...