Introduction: In this study we compared transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEPs) in a postural (bilateral low back extension: BLBE) and a respiratory (forced expiration during breath holding: FEBH) task.Methods: Using TMS of the left motor cortex, simultaneous patterns of corticospinal facilitation of the contralateral erector spinae (ES) and rectus abdomi...

ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc ε RI-mediated mast cell responses. However, in addition to their pathogenic roles in allergic and autoimmune diseases, mast cells are important in fighting infection, wound healing, and resolving inflammation, r...

The vast landscape of environmental chemicals has motivated the need for alternative methods to traditional whole-animal bioassays in toxicity testing. Embryonic stem (ES) cells provide an in vitro model of embryonic development and an alternative method for assessing developmental toxicity. Here, we evaluated 309 environmental chemicals, mostly food-use pesticides, from the ToxCast™ chemical l...

BACKGROUND The fibroblast growth factor (FGF) family is essential to normal heart development. Yet, its contribution to cardiomyocyte differentiation from stem cells has not been systemically studied. In this study, we examined the mechanisms and characters of cardiomyocyte differentiation from FGF family protein treated embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. METH...

Chronic alcohol consumption causes alcoholic liver disease, which is associated with the initiation of dysregulated lipid metabolism. Recent evidences suggest that dysregulated cholesterol metabolism plays an important role in the pathogenesis of alcoholic fatty liver disease. Ecklonia stolonifera (ES), a perennial brown marine alga that belongs to the family Laminariaceae, is rich in phlorotan...

Different methods have been proposed in the past few years to incite explosive synchronization (ES) Kuramoto phase oscillators. In this work, we show that introduction of a shift α interlayer coupling terms two-layer multiplex network oscillators can also instigate ES layers. As → π / 2, emerges along with hysteresis. The width hysteresis depends on α, strength, and natural frequency mismatch b...

BACKGROUND This study examines the reliability and validity of the Portuguese version of the Empowerment Scale (ES) to be used in the community/psychosocial mental health field. Authors also reviewed the properties of the development and cross-cultural adaptation of the ES. Because mental health services are required to encourage empowerment and recovery-oriented interventions, adequate empower...

"The child is father of the man" is the philosophy of the paediatrician, hence the recent trend of intense interest in child development, which embraces the study of factors which influence the growth of the body, mind, personality and spirit from conception to maturity and ultimate achievement. As practitioners of medicine it is natural that much of our effort should be used in the diagnosis a...

Evolution Strategies (ES) are a class of Evolutionary Algorithms based on Gaussian mutation and deterministic selection. Gaussian mutation captures pair-wise dependencies between the variables through a covariance matrix. Covariance Matrix Adaptation (CMA) is a method to update this covariance matrix. In this paper, the CMA-ES, which has found many applications in solving continuous optimizatio...