Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, and inflammatory response. However, little is known about the effect of Rev-erb agonist on the progression of myocardial infarction (MI) and heart failure. To investigate it, wild-type male mice underwent sham-operation or permanent ligation of the left anterior descending coron...

INTRODUCTION The immune modulatory role of estrogens in inflammation is complex. Both pro- and anti-inflammatory effects of estrogens have been described. Estrogens bind both estrogen receptor (ER)alpha and beta. The contribution of ERalpha and ERbeta to ER-mediated immune modulation was studied in delayed type hypersensitivity (DTH) and in experimental arthritis METHODS ER-mediated suppressi...

Tumor cells have been found in autologous hematopoietic cell transplants used after high-dose chemotherapy. To specifically eliminate contaminating mammary tumor cells during ex vivo expansion of CD341 hematopoietic progenitor cells, we used recombinant immunotoxins (ITs) directed against cell-surface antigens expressed on mammary carcinoma cells. ITs were expressed from fusion cDNAs combining ...

The satellite total solar irradiance (TSI) database provides a valuable record for investigating models of solar variation used to interpret climate changes. The 35year ACRIM total solar irradiance (TSI) satellite composite time series has been revised using algorithm updates based on 13 years of accumulated mission experience and corrections to ACRIMSAT/ACRIM3 results for scattering and diffra...

Estrogen receptor (ER) b1 and its splice variants are expressed both in ovary and ovarian cancer. We studied the role of ERb1 and two of its splice variants in regulation of gene expression, cellular proliferation, apoptosis, and migration of an ovarian cancer cell line. In this study, we transfected SK-OV-3 ovarian cancer cells with vectors coding for ERb1 or its splice variants ERb-d125 and E...

This paper describes four computer programs that perform what were formerly management-decision functions in inventory scheduling. The first program solves the classical EOQ problem (uniform inventory usage) with quantity discounts. The second program, Economic Requirement Batching (ERB), uses dynamic programming, a heuristic search algorithm, and the relation between shipment size and material...

The study investigated the ability to detect and discriminate frequency glides under a variety of experimental conditions. The subjects distinguished between a comparison signal that either was level in frequency or was swept across a fixed frequency span, and a target signal that changed more in frequency than the comparison signal. Tone durations were 50 and 400 ms. Nominal center frequencies...

Circadian clocks in large part rely on transcriptional feedback loops. At the core of the clock machinery, the transcriptional activators CLOCK/BMAL1 (in mammals) and CLOCK/CYCLE (CLK/CYC) (in Drosophila) drive the expression of the period (per) family genes. The PER-containing complexes inhibit the activity of CLOCK/BMAL1 or CLK/CYC, thereby forming a negative feedback loop [1]. In mammals, th...