Episodic memory is the capacity to recall an event in time and place (What? Where? When?). Impaired episodic memory is a debilitating cognitive symptom in schizophrenia but is poorly controlled by currently available antipsychotic drugs. Consistent with glutamatergic abnormality in schizophrenia, the NDMA receptor antagonist, phencyclidine (PCP), induces persistent 'schizophrenia-like' symptoms...

Episodic memory is a neurocognitive (brain/mind) system, uniquely different from other memory systems, that enables human beings to remember past experiences. The notion of episodic memory was first proposed some 30 years ago. At that time it was defined in terms of materials and tasks. It was subsequently refined and elaborated in terms of ideas such as self, subjective time, and autonoetic co...

Patients with schizophrenia have pronounced deficits in memory for events--episodic memory. These deficits severely affect patients' quality of life and functional outcome, and current medications have only a modest effect, making episodic memory an important domain for translational development of clinical trial paradigms. The current article provides a brief review of the significant progress...

This study examined the effects of rehearsal on the neural substrates supporting episodic autobiographical and semantic memory. Stimuli were collected prospectively using audio recordings, thereby bringing under experimental control ecologically valid, naturalistic autobiographical stimuli. Participants documented both autobiographical and semantic stimuli over a period of 6-8 months, followed ...

Despite increasing research into the severe effects of childhood memory disorders, there is currently a paucity of evidence available to inform the design of appropriate rehabilitation strategies. Indeed, within the paediatric literature there is no model that links specific memory disorders with hypotheses for appropriate rehabilitation strategies. This paper introduces a series of interventio...

To investigate whether processing fluency or cognitive control processes underlie aging-related positivity effects in memory, we compared retrieval of words on a fluency task, and of events on an autobiographical task, in younger and older adults. No positivity effect in word output was found on the fluency task, though older adults output more neutral words. For our autobiographical task, part...

Brain oscillations are one of the core mechanisms underlying episodic memory. However, while some studies highlight the role of synchronized oscillatory activity, others highlight the role of desynchronized activity. We here describe a framework to resolve this conundrum and integrate these two opposing oscillatory behaviors. Specifically, we argue that the synchronization and desynchronization...

Two experiments explored the attention and memory processes governing sensorimotor skill. Experiment 1 compared novice and experienced golf putting performance in single-task (putting in isolation) and dual-task conditions (putting while performing an auditory word search task). At specific intervals, participants also produced episodic descriptions of specific putts. Experiment 2 assessed novi...

BACKGROUND Little is known about factors that predict transition from mild cognitive impairment to Alzheimer's disease (AD). OBJECTIVE To examine the relation of impairment in different cognitive systems to risk of developing AD in persons with mild cognitive impairment. METHODS Participants are 218 older Catholic clergy members from the Religious Orders Study. At baseline, they met criteri...

Odors are powerful cues that trigger episodic memories. However, in light of the amount of behavioral data describing the characteristics of episodic odor memory, the paucity of information available on the neural substrates of this function is startling. Furthermore, the diversity of experimental paradigms complicates the identification of a generic episodic odor memory network. We conduct a s...