PURPOSE To investigate whether inhalation of ethyl pyruvate (EP) encapsulated with poly(ethylene glycol)-block-lactide/glycolide copolymer nanoparticles (EP-NPs) can prevent the development of shunt-flow-induced hyperkinetic pulmonary arterial hypertension (PAH) in a rat model. MATERIALS AND METHODS Rats were separated into five groups: blank (ie, no treatment after shunt flow), normal contro...

Erythropoietin (EP) mRNA was measured in normal and anemic mice during fetal and postnatal development. Normal fetal livers at 14 d of gestation contained a low level of EP mRNA. By day 19 of gestation, no EP mRNA was detected in normal or anemic fetal livers or normal fetal kidneys, but anemic fetal kidneys had low levels of EP mRNA. Newborn through adult stage mice responded to anemia by accu...

Objective Cyclophosphamide (CP) is a chemotherapy drug which causes deleterious effects on testicular tissue and increases free radicals in the body. The aim of this study is to investigate the protective effects of ethyl pyruvate (EP) on testicular improvement in CP treated animals. MaterialsAndMethods In this experimental study, 15 male mice (6-8 weeks) were divided into 3 groups. The control...

Background Cyclophosphamide (CP) is a chemotherapeuticdrug which causes deleterious effects on tissue of testicle and increases free radicals in the body. The aim of this study is to investigate protective effects of ethyl pyruvate (EP) on improvement of testicle inCP treated animals. MaterialsAndMethods In this study, 15 male mice(6-8 weeks) were divided into 3 groups. Control group receivedno...

A B S T R A C T To determine the plasma epinephrine thresholds for its metabolic and hemodynamic actions and plasma epinephrine metabolic clearance rates, 60-min intravenous epinephrine infusions at nominal rates of 0.1, 0.5, 1.0, 2.5, and 5.0,ug/min were performed in each of six normal human subjects. These 30 infusions resulted in steady-state plasma epinephrine concentrations ranging from 24...

UNLABELLED Face lift dissections are believed to compromise skin flap circulation, possibly leading to wound healing complications. To reduce blood loss, plastic surgeons commonly inject a solution of local anesthetic that contains epinephrine. However, the effect of surgery on skin perfusion and the degree of vasoconstriction caused by the epinephrine have not been quantitated. Little informat...

Epinephrine, a non-specific adrenergic agonist, is one of the most commonly used inotropes perioperatively. Recent studies have shown that inflammatory response in cardiac surgery could result in hypoperfusion, dysrhythmias, myocardial ischemia, and other pathophysiological alterations in the postoperative period. These alterations might be contributing to the adverse clinical outcome. Although...

Procedures have been developed to label human erythropoietin (Ep) with biotin to detect and isolate the Ep-receptor. The labeling method used the abundant carbohydrate groups on Ep and resulted in biologically active biotin-Ep (b-Ep) containing 8 to 10 biotins per Ep molecule. Specific binding of b-Ep to cells from spleens of mice made anemic by phenylhydrazine injections was demonstrated using...

Inclusive production of D(2010) mesons in deep inelastic scattering has been measured using ep and ep data obtained with the ZEUS detector at HERA using integrated luminosities of 16.7 and 65.2pb, respectively. The decay channel D → Dπ with D → Kπ and corresponding antiparticle decays were used to identify D mesons. The D cross sections in ep and ep interactions agree with NLO QCD predictions, ...