A new study calls into question whether phytochromeB (phyB)mustdirectly interact with phytochrome-interacting factors (PIFs) to promote light responses. Phytochrome photoreceptors mediate responses to red light in part by inducing the degradation of PIF transcription factors, which generally are repressors of light responses (reviewed in Jeong and Choi, 2013; Wang and Wang, 2015).As thename imp...

Desmocollin 3 (DSC3) belongs to a subfamily of cadherins and is a major component of desmosomes in keratinocytes of stratified epithelia, such as the epidermis. Based on its amino acid sequence homology to classical cadherins, such as E-cadherin, it has been postulated that DSC3 functions as a cell-adhesion molecule. To test this hypothesis, we assessed the function of DSC3 in the development a...

The non-involved, healthy-looking skin of psoriatic patients displays inherent characteristics that make it prone to develop typical psoriatic symptoms. Our primary aim was to identify genes and proteins that are differentially regulated in the non-involved psoriatic and the normal epidermis, and to discover regulatory networks responsible for these differences. A cDNA microarray experiment was...

Although mutations in the mammalian hairless (Hr) gene result in congenital hair loss disorders in both mice and humans, the precise role of Hr in skin biology remains unknown. We have shown that the protein encoded by Hr (HR) functions as a nuclear receptor co-repressor. To address the role of HR in vivo, we generated a loss-of-function (Hr-/-) mouse model. The Hr-/- phenotype includes both ha...

Sir, A thirty-year-old male received influenza vaccination in the upper arm. Several days later, erythema appeared on vaccinated site and spread to trunk extremities. He had no family history of psoriasis. was treated with a topical corticosteroid for three months, which yielded effects and, thus, he referred our hospital. physical examination revealed numerous erythematous, scaly macules scatt...

Single-cell RNA seq analyses on human epidermis have given new insights into cell fates of the tissue by characterizing precise transcriptomic profile at single-cell scale, but information spatial localizations transcripts in each single cells is lacking. 3D are therefore great importance to characterize with resolution. To study epidermal biology and diseases, organotypic models can be grown u...

The specification of distinct cell types in multicellular organisms is accomplished via establishment of differential gene expression. A major question is the nature of the mechanisms that establish this differential expression in time and space. In plants, the formation of the hair and non-hair cell types in the root epidermis has been used as a model to understand regulation of cell specifica...

The early literature of light microscopy was rich in excellent descriptions of the large and beautiful cells of amphibians. The mucous cells of the epidermis of larval salamanders, rarely mentioned in the cytological literature today, received considerable attention in this earlier era. Described by Leydig (1) in 1857, these large, round cells are so common over the body of the larva that in so...

Pathogenic memory T cells are implicated in the local relapse of allergic contact dermatitis (ACD), vitiligo and psoriasis. Here we investigate how resident initiate relapses response to allergen Methylisothiazolinone (MI). MI–related ACD was sampled two months years after resolution disease. were activated skin explants with MI or pan T-cell agonist OKT-3. Epidermis analysed by RNAseq, Nanostr...

The outer skin of a higher plant consists of a single layer of cells known as the epidermis. The epidermal layer is established during embryogenesis and is formed continually by cell division in meristems in the developing apices of the root and shoot. The epidermis expands by cell division and cell elongation as the plant grows. In addition to the relatively unspecialised epidermal cells, more...