Fifty-five retinoblastoma specimens were studied by a sensitive immunoperoxidase method to determine the intermediate filament types present in human retina and retinoblastoma. Polyclonal antiserum against vimentin and monoclonal antibodies to glial fibrillary acidic protein (GFAP) and to the 200 kD neurofilament triplet protein were used. In the human retina, Müller's cells coexpressed vimenti...

Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the abundance of work demonstrating the molecular function and identifying binding partners of pRb, t...

OBJECTIVE To review cases of retinoblastoma. SETTING Department of Pathology Aga Khan University Hospital Karachi. METHOD Twenty-three specimens from cases of retinoblastoma received over a period of eight years were routinely processes and stained with haematoxylin and Eosin stain. Other stains were used for tuberculoses and melanin. Immunochemistry was resorted to in undifferentiated tumo...

scorpion sting is a common important health problem in south-west of iran. the present descriptive retrospective study was conducted to make new information on scorpionism in the lordegan county(2002- 2006). data collected in this study revealed that the highest incidence of scorpion sting cases was taken place in spring (49.72%) in 2006. the scorpions which have brought by the pateints to t...

We report of a young African child with giant retinoblastoma originating from the left orbital space. The mother and Cameroon seeking medical support at Department Pediatrics. To date arrival, extensive tumor was exulcerating not curable. Only palliative possible.

BACKGROUND Enucleation (eye removal) is often the only curative treatment for the childhood eye cancer retinoblastoma, yet parental refusal of enucleation commonly contributes to treatment delay and poor survival globally. METHODS Physicians who treat retinoblastoma were surveyed to glean underlying reasons for treatment refusal. RESULTS Refusal rates were higher when less time was spent wi...

Fc and C3b receptors were identified on cultured retinoblastoma cells. Labeled receptor protein bound to affinity gels prepared with IgG, Aggregated IgG, and Fc but not to control gels prepared from Fab'2 or Sepharose-4B alone. Eluted Fc receptors was partially characterized by polyacrylamide gel electrophoresis. Molecular weight of the isolated receptor or its subunit was approximately 4.3 X 1...

background: the role of retinoblastoma (rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including habits such as smoking, paan chewing, and alcoholism. materials and methods: this observational study included surgical specimens from 10 apparen...

The aim of the present review is to give new insights into the pathogenesis of retinoblastoma, by applying the principles of epigenetics to the study of clinical, epidemiological and biological data concerning the disease. As an emerging new scientific approach linking the genome to the environment, epigenetics, can not only explain the inconsistencies of the mutational (‘two hit’) model in the...

Retinoblastoma accounts for 6% of pediatric malignancies under the age of 5 years in the United States, (Broaddus et al., 2008) and epidemiological data suggest that the incidence is standard across populations (Kivelä, 2009). Despite its rarity, observations about the pathogenesis of this disease have enhanced our understanding of genetic cancer syndromes. Germinal or hereditary cases comprise...