نتایج جستجو برای: epha2
تعداد نتایج: 800 فیلتر نتایج به سال:
The present study aimed to investigate whether 17β‑estradiol (E2) exerts protective effects on bone deterioration induced by ovariectomy (OVX) through the ephA2/ephrinA2 signaling pathway in rats. Female rats were subjected to OVX, sham surgeryor OVX+E2 treatment. Levels of biomarkers were measured in serum and urine. Hematoxylin and eosin staining was performed on paraffin‑embedded bone sectio...
PURPOSE Congenital cataracts occur in 3-4 per 10,000 live births and account for 5% to 20% of pediatric blindness worldwide. With more than 37 genes known to be associated with isolated congenital cataract, whole exome sequencing (WES) was recently introduced as an efficient method for screening all known factors. METHODS Whole exome analysis in two members of a four-generation pedigree affec...
The epithelial cells exhibit either a columnar or a flat shape dependent on extracellular stimuli or the cell-cell adhesion. Membrane-anchored ephrinA stimulates EphA receptor tyrosine kinases as a ligand in a cell-cell contact-dependent manner. The mechanism through which ephrinA1/EphA2 signal regulates the cell morphology remains elusive. We demonstrate here that ephrinA1/EphA2 signal induces...
RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, we report on a novel approach to overcome these limitations using a multistage vector composed of mesoporous silicon particles (stage 1 micropart...
Overexpression of the receptor tyrosine kinase EphA2 occurs in non–small cell lung cancer (NSCLC) and a number of other human cancers. This overexpression correlates with a poor prognosis, smoking, and the presence of Kirsten rat sarcoma (K-Ras) mutations in NSCLC. In other cancers, EphA2 has been implicated in migration and metastasis. To determine if EphA2 can promote NSCLC progression, we ex...
Purpose: To investigate the effects of miR-34a and miR-26b on targeted genes, LEF1 EphA2, proliferation apoptosis OPCN-1.Methods: Sixty specimens cancer tissue (CT) equivalent adjacent to tumors (TAT) were collected from prostate patients. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used determine mRNA expression levels miR-34a, miR-26b, LEF1, EphA2 in above tissu...
Abstract One of the key challenges in development CAR-T therapy is absence target antigens that are tumor-specific and have homogenous expression. To safely glioblastoma-associated (GAAs) tumor without attacking normal tissue expressing same GAAs outside brain, we adapted a novel synthetic Notch (synNotch) receptor system established “prime kill” sequential two-receptor CAR circuit. We used gli...
BACKGROUND Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were not consistent. The objective of this study was to examine the role of these two gene polymorphisms in ARC susceptibility. METHODS Eligible case-control studies published betwe...
A Modified Adenovirus Vector–Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target1
BACKGROUND We constructed a genetically modified adenovirus vector incorporating an IgG Fc-binding motif from staphylococcal protein A, Z33 (Adv-FZ33). Adv-FZ33 allows an antibody to redirect the vector to a target molecule on the cell surface. We attempted to search for target antigen candidates and antibodies that allowed highly selective gene transduction into malignant tumors. METHODS Hyb...
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