One health is an approach that gains importance in the protection of public and advocates environment-animal-human linked. Microbial resistance occurring any these three factors circulates directly or indirectly between species affects health. In this study, antimicrobial, anti-quorum sensing activity potential probiotic properties Lactobacillus acidophilus Enterococcus faecalis 1 2 isolates fr...

Diabetes is a complex metabolic disease characterized by plasma hyperglycemia. One of theways treatment diabetes the inhibition pancreatic α-amylase. However, drugsavailable in market carry out range side effects. Therefore, present work aimed toevaluate effect tamarind waste (skin and seed) rejected food industry on theactivity Hydroethanolic extract (70%) skin seedwere prepared, lyophilized, ...

Abstract: Aim/ Background: Pancreatic lipase (PL) inhibition has been suggested to be an effective method for obesity management. In this study, 10 novel thiazole-benzimidazole conjugates were designed. Materials and Methods: Conjugates initially screened via in silico experiments, such as ADMET analysis molecular docking, identify the most promising PL inhibitors. Results: Results revealed tha...

Activation of plasminogen by urokinase plasminogen activator (uPA) plays important roles in several physiologic and pathologic conditions. Cells secrete uPA as a single-chain molecule (scuPA). scuPA can be activated by proteolytic cleavage to a 2-chain enzyme (tcuPA). scuPA is also activated when it binds to its receptor (uPAR). The mechanism by which the enzymatic activity of the scuPA/suPAR c...

Enzymes that degrade cellulose into glucose are one of the most expensive components of processes for converting cellulosic biomass to fuels and chemicals. Cellulase enzyme Cel7A is the most abundant enzyme naturally employed by fungi to depolymerize cellulose, and like other cellulases is inhibited by its product, cellobiose. There is thus great economic incentive for minimizing the detrimenta...

conclusions all plants could inhibit mushroom tyrosinase, but more investigations on human tyrosinase and clinical studies are needed. results the hydroalcoholic extract of p. alkekengi showed the most tyrosinase inhibitory effect with ic50 of 0.09 mg/ml vs. 0.38, 0.38 and 2.82 mg/ml of b. persicum, a. rosea and m. vulgare, respectively. m. vulgare exhibited uncompetitive inhibition and other p...

Enzymatic hydrolysis of cellulose is a complex process because of a number of inhibition and enzyme inactivation reactions which happen during hydrolysis. Artificial Neural Networks (ANNs) are very effective in developing predictive models for processes involving complex reaction kinetics that would otherwise be difficult to be modeled by more traditional deterministic approaches. The present i...

Conformations and catalytic rates of enzymes (biological catalysts) fluctuate over a wide range of time scales. Recent experimental and theoretical investigations demonstrated case studies where the enzymatic catalysis rate follows the Michaelis-Menten (MM) rate law despite molecular fluctuations. In this paper, we investigate deviations from MM law and their effects on the dynamical behavior o...

This work evaluates the possibility of applying enzymatic beech wood (Fagus sylvatica) hydrolysate as a feedstock for Chlorella sorokiniana growth, and fatty acid and pigment production. Beech wood solids were pretreated with NaOH at high temperature to partially remove xylose and Klason lignin, and enable production of glucose during subsequent enzymatic hydrolysis. Neutralized wood enzymatic ...