A new study by Sennino and colleagues demonstrates that selective VEGF inhibition via the use of an anti-VEGF antibody is sufficient to increase invasion and metastasis in a c-Met-dependent manner. Anti-VEGF therapy induced tumor hypoxia, hypoxia-inducible factor 1α, and c-Met activation in the RIP-Tag2 model of neuroendocrine pancreatic cancer. Selective c-Met inhibition was sufficient to bloc...

Abstract Standard brick walls have caused a gradual increase in the area’s temperature due to bricks’ emissivity. Therefore, several effective technologies overcome this problem been proposed, one of which is thermal insulation by covering outer bricks from exposure sunlight. This study compares effectiveness with Glass Fiber Reinforced Cement (GRC) and Expanded Polystyrene (EPS) material obtai...

A successful urban planning and design solution ought to present a comfortable setting for its pedestrians inside urban canyons, because it is fundamental to encourage a good quality urban life and promote health and wellbeing of humans. Recent findings have demonstrated that microclimate inside urban canyons has substantial influence upon the outdoor thermal comfort at the street level .This s...

In the last decades, several studies have revealed how critical the urban heat island (UHI) effect can be in cities located in cold climates, such as the Canadian one. Meanwhile, many researchers have looked at the impact of the city design over the urban microclimate, and have raised concerns about the development of too dense cities. Under the effect of the “Places to Growth” plan, the city o...

Background: This st udy aims t o evaluat e t he associat ion bet ween envi ronment al and socio-economic condit ions wit h asthma prevalence in t he eight ISAAC cent res in North-East Brazil. Met hods: Est imates on occurrence, severit y and medical diagnoses of asthma in the previous 12 months were compared using environmental and socioeconomic indicators. Associat ions were assessed using sim...

Salcedo Village has become more susceptible to urban heat effects because of its continuous development. This study investigates urban retrofit strategies that effectively mitigates the heat through modelling and simulation in ENVI-met. It is identified to have a maximum of 1-1.4K heat increase over 100% of its area, recorded during December 23:00 at 2m from the ground. The temperature increase...

The utilization of urban green zones forms a major part of urban sustainability in the context of the improvement of quality of life of the citizens. Within the policy for sustainable management of urban green zones, the tools that are used effectively are new technologies such as web databases, web DSS, GIS and environmental impact prediction model. This paper presents the geodatabase, which w...

This paper investigates urban bioclimatic interventions in the central area of a coastal medium-sized city in Greece. Two urban blocks typical of the urban fabric of the city center and a neighborhood of 38 urban blocks were selected. Different proposed Bioclimatic Renewal Scenarios were investigated through microclimatic simulations using the micro-scale numerical model, ENVI-met. The simulati...

The urban heat island (UHI) effect is among the most critical issues caused by human activities and high building density. UHI has severe impacts on natural environment as well health wellbeing. research presented here aims at evaluating effects of nature-based solutions (NBS) in improving livability a district city Genoa, which heavily cemented major example phenomenon. This study focuses micr...

Collerton et al.’s Perception and Attention Deficit (PAD) model argues that all recurrent complex visual hallucinations (RCVH) result from maladaptive, deficient sensory and attentional processing. We outline a constructivist-based representation of perception using signal detection theory, in which hallucinations are modeled as false alarms when confirmational perceptual information is lacking...