therapy in resistant enteric fever, various drugs singly, or in combination, such as cotrimoxazole and cephalosporins, or cephalexin and gentamicin, third generation cephalosporins and newer quinolones have been tried with varying results. This communication describes our observations on the clinical profile of children with enteric fever due to MDRST infection and, compare different drug regim...

BACKGROUND Improvements in endoscopy center efficiency are needed, but scant data are available. OBJECTIVE To identify opportunities to improve patient throughput while balancing resource use and patient wait times in a safety-net endoscopy center. SETTING Safety-net endoscopy center. PATIENTS Outpatients undergoing endoscopy. INTERVENTION A time and motion study was performed and a dis...

BACKGROUND This study was done to evaluate the relationship between the time of endoscopy in patients with upper gastrointestinal bleeding with morbidity and mortality rates of patients at the Al Zahra Hospital emergency room. MATERIALS AND METHODS In a cohort study, 1152 patients at 2014 and 2015 have been hospitalized due to gastrointestinal bleeding in Al Zahra Hospital, were selected and ...

Ulcerative colitis (UC) is a leading form of inflammatory bowel disease that involves chronic relapsing or progressive inflammation. As a significant proportion of UC patients treated with conventional therapies do not achieve remission, there is a pressing need for the development of more effective therapies. The human gut contains a large, diverse, and dynamic population of microorganisms, co...

The enteric nervous system may have an important role in modulating gastrointestinal barrier response to disease through activation of enteric glia cells. In vitro studies have shown that enteric glia activation improves intestinal epithelial barrier function by altering the expression of tight junction proteins. We hypothesized that severe injury would increase expression of glial fibrillary a...

gamma-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABA(A) or inhibitory GABA(B) receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.

Experience has shown that neither drugs nor vaccines can hope to solve the world's enteric disease problems. But oral-fluid therapy, which has sharply reduced cholera mortality, is proving effective in treating other enteric diseases as well. And most developing countries are making real progress in providing the safe water supplies and sanitary conditions that deny enteric pathogens an opportu...

We investigated the indications for and findings of gastrointestinal (GI) endoscopy in all children < or = 16 years old referred for the procedure to the endoscopy unit at Soba University Hospital, Khartoum from January 2004 to January 2006. Thus 113 children were enrolled; 73% underwent upper GI endoscopy, 27% lower GI endoscopy (15% colonoscopy, 12% flexible sigmoidoscopy). Indications for up...