EDP-420 (EP-013420, S-013420) is a first-in-class bicyclolide (bridged bicyclic macrolide) currently in clinical development for the treatment of respiratory tract infections. It has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including Haemophilus influenzae, atypical organisms (e.g....

We propose a robust optimization approach to address a multi-period, inventory control problem under ambiguous demands, that is, only limited information of the demand distributions such as mean, support and some measures of deviations. Our framework extends to correlated demands and is developed around a factor-based model, which has the ability to incorporate business factors as well as time ...

articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. the scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. cartilage tissue engineering requires 3 components: cells, scaffold, and environment. owning to their ...

Applications are becoming more complex, more larger and demand high quality. Application Server is the component on which most of the applications are hosted. It acts in the middle tier providing lot of functionalities like transaction management, caching ,persistence clustering etc. There are a variety of application servers to choose from like JBoss, Websphere, Tomcat etc, some are open sourc...

BACKGROUND One of the observer errors associated with blood pressure (BP) measurement using a mercury sphygmomanometer is end digit preference (EDP) which refers to the occurrence of a particular end digit more frequently than would be expected by chance alone. Published reports, mainly from outside Africa, have shown a high prevalence ranging from 22 to 90% of end digit zero in BP readings tak...

This paper presents a novel extended dynamic programming approach for energy minimization (EDP) to solve the correspondence problem for stereo and motion. A significant speedup is achieved using a recursive minimum search strategy (RMS). The mentioned speedup is particularly important if the disparity space is 2D as well as 3D. The proposed RMS can also be applied in the well-known dynamic prog...

Abstract Background Women with signs and symptoms of ischemia no obstructive coronary arteries (INOCA) have evidence diastolic dysfunction are at increased risk developing heart failure preserved ejection fraction (HFpEF). However, mechanisms contributing to HFpEF development poorly understood often attributed underlying cardiovascular factors. Purpose To compare clinical, invasive, imaging par...

The advancements in distributed computing have driven the emergence of service-based infrastructures that allow for on-demand provision of ICT assets. Taking into consideration the complexity of distributed environments, significant challenges exist in providing and managing the offered on-demand resources with the required level of Quality of Service (QoS), especially for real-time interactive...

In this article, an integrated model is developed in which a manufacturer purchases raw materials from a supplier, and then produces finished products/goods, after that delivers them to a buyer. In the intended model production rate is assumed as a function of demand rate and customer demand rate is time dependent. To make the model more realistic the effect of inflation and time value of money...