The structural change in the tight junction between human endometrial epithelial cells during the normal menstrual cycle was observed by means of freeze-fracture replica electron microscopy. Tight junctions between epithelial cells of the endometrial basal layer showed no alterations in structure during the menstrual cycle, while those between epithelial cells of the functional layer exhibited ...

The recently identified trans-membrane G protein-coupled estrogen receptor 1 (GPER, GPR30) has been implicated in rapid non-genomic effects of estrogens. This focuses on expression and localization of GPER mRNA and protein in normal cyclic endometrium and early pregnancy decidua. Real-time PCR, western blotting, in situ hybridization and immuno-histochemistry were used. Endometrial expression o...

Endometrial stromal sarcomas are rare gynecologic malignancies characterized by the presence of cells that resemble those of the endometrial stroma during the prolipferative phase of the menstrual cycle. They are classified as low grade or high grade tumors depending on the mitotic index, the second one being usually associated with poor prognosis and high recurrence rate. We present the case o...

Human endometrium expresses numerous genes to achieve an optimal uterine environment for implantation and maintaining the pregnancy. In this review, we will summarize our previous observations on progestin regulated gene expression, estrogen metabolic enzymes, nitric oxide synthase, aromatase, IGF-I and II, IGFBP-1, prolactin and glycodelin. These genes are differentially activated in two types...

Even though the physiological role of estrogen in the female reproductive cycle and endometrial proliferative phase is well established, the signaling pathways by which estrogen exerts its action in the endometrial tissue are still little known. In this regard, advancements in cell culture techniques and maintenance of endometrial cells in cultures enabled the discovery of new signaling mechani...

background: natural endometrium in frozen-thawed embryo transfer (fet) may have some benefits upon implantation in patients with repeated implantation failure (rif). it might be due to possible differences between natural and stimulated endometrial growth factors and cytokins secretions. objective: the objective of this study was to compare the pregnancy rate of fet on modified natural cycle ve...

BACKGROUND Cell cycle proteins and HIF-1alpha with downstream factors are often abberrantly expressed in (pre)neoplastic tissue. METHODS Paraffin-embedded specimens of inactive endometrium with TM (n=15), ovarian inclusion cysts (n=6), cervix with TM (tubal metaplasia) (n=3), Fallopian tubes (n=7), cycling endometrium (n=9) and a ciliated cell tumor of the ovary were stained for p16 and LhS28...

BACKGROUND Because unopposed estrogen substantially increases endometrial carcinoma risk, estrogen plus progestin is one menopausal hormone therapy formulation for women who have not had a hysterectomy. However, endometrial carcinoma risks among estrogen plus progestin users and among former unopposed estrogen users are not firmly established. METHODS We evaluated endometrial carcinoma risks ...

This study describes histology and ultrastructure of uterus in the African giant rat during oestrous cycle. Endometrial histology displayed glandular mucosa consisting of lamina epithelialis and lamina propria mucosae. Its epithelium varied between simple and pseudostratified columnar. The myometrium consisted of inner circular and outer longitudinal smooth muscles with medium sized arteries an...

The impact of a premature elevation of serum progesterone level, the day of hCG administration in patients under controlled ovarian stimulation during IVF procedure, on human endometrial receptivity is still debated. In the present study, we investigated the endometrial gene expression profile shifts during the prereceptive and receptive secretory stage in patients with normal and elevated seru...