Intensive research work has been performed to better understand the regulation of the endometrium and its clinical implications to improve implantation. Although many proteins and molecules may influence endometrial development, their co-ordinated contribution to the implantation process is still poorly understood and a translation into clinical use has not sufficiently been performed. Clinical...

Endometrial cancer is the most common gynecologic malignancy. It is the fourth most common cancer in women in the United States after breast, lung, and colorectal cancers. Risk factors are related to excessive unopposed exposure of the endometrium to estrogen, including unopposed estrogen therapy, early menarche, late menopause, tamoxifen therapy, nulliparity, infertility or failure to ovulate,...

BACKGROUND Unopposed estrogen has a central role in development of endometrial benign, premalignant and malignant lesions. The aim of this study was to evaluate the anti-estrogenic effect of metformin on endometrial histology in comparison with progesterone. MATERIALS AND METHODS A total of 43 patients who were referred to our center for abnormal uterine bleeding and had a histologic diagnosi...

1 Associate Professor, Department of obstetrics and gynecology, Kannur Medical College, Anjarakandy 2 Professor, Department of obstetrics and gynecology, Kannur Medical College, Anjarakandy ABSTRACT Aim: To study the endometrial pathology in patients with perimenopausal and postmenopausal bleeding by using transvaginal ultrasound, hysteroscopy and histopathology To compare the sonographically m...

Our patient, a 68-year-old Caucasian female, had a 4to-6-week history of postmenopausal vaginal bleeding requiring more than 2 pads per day. Pelvic ultrasound demonstrated uterine prominence (8.6 cm x 6.1 cm x 4.9 cm) with thickening of the endometrial complex (1.2 cm), as well as uterine fibroids (Fig. 1). An endometrial biopsy demonstrated diffuse large B-cell lymphoma, CD-20 positive (Fig. 2...

Eighty-eight endometrial specimens from 36 postmenopausal breast cancer patients treated with tamoxifen were investigated cytogenetically and molecularly using fluorescence in situ hybridization with appropriate probes for the HMGIC and HMGIY genes. Twenty control specimens, 10 endometrial polyps, and 10 endometrial biopsy specimens were investigated in the same way. Of the 88 specimens, 44 wer...

The incidence and mortality rate of endometrial cancer has been registering an increasing trend both in Romania and in the whole world. The paper's aim is to analyze the diagnostic approach of endometrial pathology in the University Emergency Hospital Bucharest, on a four years period. The medium age of the patients was of 50.51 ± 10.924 years, and the median age was of 48 years. The youngest p...

Endometrial calcifications occur sporadically and are associated with infertility. Previous uterine trauma during instrumentation and/or uterine infection are likely involved in their pathogenesis. The association between endometrial calcifications and recurrent pregnancy loss has been very infrequently reported. A 28-year-old woman with a history of two consecutive first trimester pregnancy lo...