Objective: To investigate the expression and significance of Insulin like growth factor-II mRNA binding protein 3 (IMP3) and P16INK4a in adenocarcinoma of the uterine cervix. Methods: Immunohistochemical method was used to detect the expression of IMP3(SP method) and P16INK4a (EnVision) in 25 cases of benign endocervical glands (BEG), 15 cases of endocervical adenocarcinoma in situ (AIS) and 56...

Most cervical adenocarcinomas currently are HPV related. With increasing use of vaccine, the prevalence related carcinomas may reduce & there might be relative increase in occurrence non carcinomas. Gastric variant adenocarcinoma is one such HPV-independent carcinoma and recognized as distinct entity by WHO 2014. A spectrum benign, premalignant malignant endocervical lesions showing gastric...

The importance of cervical squamous metaplasia and human papillomavirus 16 (HPV 16) infection for cervical carcinoma has been well established. Nearly 87% of the intraepithelial neoplasia of the cervix occur in the transformation zone, which is composed of squamous metaplastic cells with unclear origin. HPV DNA, mostly HPV 16, has been found in 90% of cervical carcinomas, but only limited exper...

OBJECTIVE To determine the impact of not keeping the collecting device in liquid-based cytology. Loss of material was computed from a pair of subsamples from the same cervical scrape. One subsample was obtained by rinsing the collecting device in one vial and the other by discarding it in another vial. Homogeneity of endocervical component was assessed between subsamples. MATERIALS AND METHOD...

The aim of the present study was to explore the histogenesis of metaplastic cells in the human uterine cervix. In a previous study we demonstrated that squamous cervical metaplasia expresses a unique set of cytokeratin polypeptides different from that expressed by the various normal epithelial elements of both the exo- and endocervix. It was thus proposed that the formation of squamous metaplas...

OBJECTIVE The purpose of this study was to evaluate the Amplicor Chlamydia trachomatis Test (Roche Molecular Systems, Branchburg, NJ), a polymerase chain reaction (PCR)-based technique, as a screening test for the detection of female urogenital C. trachomatis infections, comparing it to an enzyme immunoassay method. METHODS Endocervical specimens for PCR and Chlamydiazyme (Abbott Laboratories...

A modified sanitary napkin was compared with endocervical swab and urine specimens for the detection of urogenital Chlamydia trachomatis infection. Endocervical swabs and/or first-catch urine were collected from 510 women at medical or community settings in Quebec City. Participants were also asked to wear a modified sanitary napkin (Ezy-Detek) during 4 consecutive hours and to bring it back to...

•The case presented is that of a primary debulking surgery for presumed ovarian cancer.•Final pathology revealed diffusely metastatic endocervical adenocarcinoma.•After primary chemotherapy, the patient has remained disease-free 30 months after surgery.

Objective: This study was conducted using the human papillomavirus (HPV) DNA chip test (HDC), in order to determine whether the HPV genotype is a predictor of residual disease in a subsequent hysterectomy following a loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 3. Methods: Between January 2002 and February 2015, a total of 189 patients who underwen...