In this study, 6-azido-2,3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and bonded onto aminized silica gel to obtain a new chiral stationary phase. Enantioselectivity of the chiral stationary phase and Chiralcel OF suggested promising chiral separation ability of the new cellulose chiral stationary phase. In addition, the effect of trifluoroacetic acid, diethylamine on enantiosele...

[Ru(phen)2(dppz)]2+ has been studied since the 1990s due to its 'light-switch' properties. It can be used as a luminescent DNA probe, with emission switched on through DNA binding. The luminescence observed is dependent on the solvent accessibility of the pyrazine nitrogen atoms, and therefore is sensitive to changes in both binding site of the cation and chromophore orientation. The compound i...

A chiral bispyrene macrocycle designed for exclusive intermolecular excimer fluorescence upon aggregation was synthesized by a double hydrothiolation of bis-enol ether followed intramolecular oxidation free thiols. Unusually high stereoselectivity achieved the thiol-ene additions under templated conditions and Et3B/O2 radical initiation. After enantiomer separation (chiral stationary phase HPLC...

We report a theoretical study of the first silver-dependent enantiodivergent gold-catalysed reaction. The combination single chiral binuclear gold(I) chloride complex and silver perchlorate catalyses asymmetric intramolecular hydroamination alkenes affords both enantiomers products by applying simple solvent change from toluene to methanol. A gold-silver adduct that occurs only in methanol appe...

The reactions with DNA and mutagenic activities toward Salmonella typhimurium TA 100 of the R,S,S,R and S,R,R,S enantiomers of anti-1,2,-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (anti-5-MeC-1,2-diol-3,4-epoxide), anti-5-MeC-7,8-diol-9,10-epoxide, and anti-6-MeC-1,2-diol-3,4-epoxide were compared because among these compounds only the R,S,S,R enantiomer of anti-5-MeC-1,2-diol-3,4-...

Citalopram is a serotonin-selective reuptake inhibitor (SSRI) widely used in the treatment of major depression and sometimes also anxiety-associated conditions, obsessive compulsive disorder and behavior disturbances associated with dementia [1, 2]. Citalopram is relatively well tolerated and has been considered to have comparatively low potential for drug–drug interactions and anti-adrenergic ...

Bioassays of six racemic synthesized candidate sex pheromone compounds against male New World screwworm Cochliomyia hominivorax (Coquerel) flies showed that the most potent bioactivity was found with 6-acetoxy-19-methylnonacosane and 7-acetoxy-15-methylnonacosane compared with four other isomeric acetoxy nonacosanes and a larger aliphatic ketone. As all these methyl-branched compounds have two ...