The advent of next-generation sequencing technology has allowed the collection of vast amounts of genetic variation data. A recurring discovery from studying larger and larger samples of individuals had been the extreme, previously unexpected, excess of very rare genetic variants, which has been shown to be mostly due to the recent explosive growth of human populations. Here, we review recent l...

The paper covers questions relating to the existence, explosion, and prevention of explosion, of solutions of stochastic functional differential equations (SFDEs) of Itô type. It is well-known that solutions of a deterministic ordinary differential equation x(t) = f(x(t)) can explode in finite time if the function f does not obey a global linear bound; however, uniqueness up to the explosion ti...

Fingerprints have been used in forensic investigations for the identification of individuals since the late 19th century. However, it is now clear that fingerprints can provide significantly more information about an individual. Here, we highlight the considerable advances in fingerprinting technology that can simultaneously provide chemical information regarding the drugs ingested and the expl...

This study is about the non-uniform electric field for splitting of water in oil emulsion. If the process occurs in an inhomogeneous electrical field, the drops are polarized and then their mobility is increased. The emulsion drops will be charged and move toward the central point of splitter where the maximum intensity of electrical field has been concentrated. In this process, the drops encou...

Ellipsoid-shaped nanoclusters composed of single superparamagnetic nanoparticles can be generated by emulsion electrospinning. Stretching and subsequent solvent evaporation of iron oxide loaded emulsion droplets during the emulsion electrospinning process enables the creation of such structures embedded in polymer nanofibers. Dissolution of the polymer fibers yields an aqueous dispersion of the...

In a prospective, randomized clinical trial, the toxicity of 1 mg of amphotericin B (AmB) per kg of body weight per day infused in 5% dextrose was compared with that of AmB infused in lipid emulsion in children with malignant disease. In an analysis of 82 children who received a full course of 6 days or more of AmB (117 courses), it was shown that there were significant increases in plasma urea...

BACKGROUND The goal of this in vitro study was to investigate the effect of lipid emulsion on vasodilation caused by toxic doses of bupivacaine and mepivacaine during contraction induced by a protein kinase C (PKC) activator, phorbol 12,13-dibutyrate (PDBu), in an isolated endothelium-denuded rat aorta. METHODS The effects of lipid emulsion on the dose-response curves induced by bupivacaine o...

Background Intermittent explosive disorder is defined as a recurrent, problematic, and impulsive aggression that affects 3% to 4% of the US population. While behavioral genetic studies report a substantial degree of genetic influence on aggression and impulsivity, epigenetic mechanisms underlying aggression and intermittent explosive disorder are not well known. Methods The sample included 44...