The present study examined the effects of diazepam (a widely used anxiolytic benzodiazepine) on the behavioural response of pigs to three novel experimental situations used to measure anxiety-related behaviour in rodents. Twelve weaned pigs (two pairs from each of the three litters) were tested in an elevated plus-maze at the age of 6 weeks, a light/dark test at the age of 7 weeks and an open-f...

Submited: January 22, 2008 Accepted: June 25, 2008 Abstract Objective: Lithium has been successfully employed to treat bipolar disorder for decades, and recently, was shown to attenuate the symptoms of other pathologies such as Alzheimer’s disease, Down’s syndrome, ischemic processes, and glutamate-mediated excitotoxicity. However, lithium’s narrow therapeutic range limits its broader use. Ther...

volatile components of three parts of pimpinella tragium vill. (umbelliferae family) from iran were investigated qualitatively and quantitatively for the first time. essential oils were isolated by hydro-distillation from stems plus leaves, inflorescence and seeds of p. tragium individually. the plant materials were collected from polour (northeast of tehran province). the yields of the stems p...

Changes in essential oil during ensiling of lemongrass and lemon eucalyptus were studied. Wilted lemongrass and eucalyptus leaves were ensiled in 0.25-L anaerobic jars. Samples consisted of a control (no additives) and a treated sample (0.5% glucose and lactic acid bacteria and 1% cellulase plus 1% hemicellulase plus pectinase). Three jars per treatment were sampled on days 2, 6, 10, and 36 for...

Volatile components of three parts of Pimpinella tragium Vill. (Umbelliferae family) from Iran were investigated qualitatively and quantitatively for the first time. Essential oils were isolated by hydro-distillation from stems plus leaves, inflorescence and seeds of P. tragium individually. The plant materials were collected from Polour (Northeast of Tehran Province). The yields of the ...

benzodiazepines (bzds) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. however, they have some undesired effects including memory problems. in continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...