The rapid gain in skeletal muscle mass in the neonate is associated with a marked elevation in skeletal muscle protein synthesis in response to feeding. The feeding-induced response decreases with development. To determine whether the response to feeding is regulated at the level of translation initiation, the expression, phosphorylation, and function of a number of eukaryotic initiation factor...

Lettuce mosaic, caused by the potyvirus LMV, is a serious viral disease of lettuce crops world-wide. Beside seed control, one of the leading strategies to control LMV is the use of the recessive resistance genes mo11 and mo12. In an attempt to characterize the functional role of the translation initiation factor eIF4E in lettuce susceptibility to LMV, we cloned Ls-eIF4E cDNAs from a collection ...

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In female fruit flies, Sex-lethal (Sxl) turns off the X chromosome dosage compensation system by a mechanism involving a combination of alternative splicing and translational repression of the male specific lethal-2 (msl-2) mRNA. A genetic screen identified the translation initiation factor eif4e as a gene that acts together with Sxl to repress expression of the Msl-2 protein. However, eif4e is...

PARN, a poly(A)-specific ribonuclease, binds the 5' cap-structure of mRNA and initiates deadenylation-dependent decay. Eukaryotic initiation factor 4E (eIF4E) also binds to the cap structure, an interaction that is critical for initiating cap-dependent translation. The stability of various mRNA transcripts in human cell lines is reduced under conditions of serum starvation as determined by both...

Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. ...

The study of eukaryotic initiation factor 4E (eIF4E) is a key focus in cancer research due to its role in controlling the translation of tumour-associated proteins, that drive an aggressive migratory phenotype. eIF4E is a limiting component of the eIF4F complex which is a critical determinant for the translation of mRNAs. Mitogen-activated protein kinase interacting protein kinases (MNK1/2) pho...

HS is a chronic inflammatory skin disorder and often associated with neoplastic growth of cSSC. Between 1%-3.2% patients develop cSCC, however, the molecular pathogenesis this disease remains undefined. Here, we demonstrate pathogenic role for 5’cap-binding protein complex eIF4F in lesion-associated This composed scaffold eIF4G, cap-binding eIF4E DEAD-box helicase eIF4A1. Employing confocal mic...