The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed reductions in cardiovascular events of 19% to 45%. These findings suggest that ...

Treatment with icosapent ethyl 4 g/day, a highly purified and stable ester of eicosapentaenoic acid (EPA), demonstrated significant reduction in atherosclerotic cardiovascular disease (ASCVD) events death REDUCE-IT. However, analyses REDUCE-IT meta-analyses have suggested that this clinical benefit is greater than can be achieved by triglyceride alone. EPA therefore may additional pleiotropic e...

Dunaliella salina is a unicellular green alga with a high α-linolenic acid (ALA) level, but a low eicosapentaenoic acid (EPA) level. In a previous analysis of the catalytic activity of delta 6 fatty acid desaturase (FADS6) from various species, FADS6 from Thalassiosira pseudonana (TpFADS6), a marine diatom, showed the highest catalytic activity for ALA. In this study, to enhance EPA production ...

background: the omega-3 fatty acid (ω-3 fatty acid) such as eicosapentaenoic acid (epa) is currently used in the clinic as a nutritional supplement in the treatment of polycystic ovarian syndrome (pcos). the present study was designed to investigate the effect of epa on the expression levels of peroxisome proliferator-activated receptor gamma (pparγ) and cytochrome p450 aromatase (encoded by th...

Huntington’s disease (Huntington’s chorea) is an autosomal dominant disease of the human brain caused by an unstable expansion of CAG trinucleotide triplet repeats in the huntingtin gene at 4p16.3; the CAG repeats are transcribed and translated into polyglutamine expansion (polyQ) stretches, and the length of the repeats correlates inversely with age of onset. Huntington’s disease is characteri...

Atrial fibrillation (AF) is the most common type of arrhythmia in general population with a prevalence that reaches one third patients arterial hypertension, diabetic and other risk factors. In atrial fibrillation, regular impulses produced by sinus node for normal heart beat are overwhelmed rapid electrical discharges atria adjacent parts pulmonary veins. Omega-3 polyunsaturated fatty acids (P...

Seasonal variations of proximate compositions and fatty acids of tench (Tinca tinca) captured from Seyhan Dam Lake were investigated. The results showed that seasonal fatty acid compositions of tench fillets in July, August and November ranged from 29.59% to 33.71% for saturated fatty acids (SFA), from 20.50% to 21.69% for monounsaturated fatty acids (MUFAs) and from 26.50% to 41.85% for polyun...

BACKGROUND Soy protein ameliorates rat polycystic kidney disease with concomitant renal enrichment of omega3-polyunsaturated fatty acids. A study was conducted to examine the effects of eicosapentaenoic acids (EPA) on renal volume and function in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS Non-azotemic patients were randomized to either a control group (n = 20)...

OBJECTIVE: In a recent study, we showed that the combination of aspirin plus the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) synergistically inhibited platelet function. As aspirin, EPA, and DHA have demonstrated anti-inflammatory properties, we hypothesized that the ingestion of EPA and DHA, with and without aspirin, would reduce plasma levels of inflammatory...

The marine oleaginous diatom Fistulifera solaris JPCC DA0580 is a candidate for biodiesel production because of its high lipid productivity. However, the substantial eicosapentaenoic acid (EPA) content in this strain would affect the biodiesel quality. On the other hand, EPA is also known as the essential health supplement for humans. EPAs are mainly incorporated into glycerolipids in the micro...