In mature B lymphocytes, the zinc finger transcription factor early growth response 1 (Egr-1) is one of the many immediate-early genes induced upon B cell antigen receptor engagement. However, its role during earlier stages of lymphopoiesis has remained unclear. By examining bone marrow B cell subsets, we found Egr-1 transcripts in pro/pre-B and immature B lymphocytes, and Egr-1 protein in pro/...

AIMS Our previous studies have shown that N-n-butyl haloperidol iodide (F2) can antagonize myocardial ischemia/reperfusion (I/R) injury by down-regulating the early growth response (Egr)-1 expression, but the molecular mechanisms are not well understood. Because there is evidence implicating myocardial I/R injury is closely associated with endothelial dysfunction. The present study is to test t...

BACKGROUND AND AIMS Helicobacter pylori, in particular cytotoxin associated gene (cag)+ strains, have been shown to enhance gastric epithelial cell proliferation in vivo, an effect that likely contributes to gastric carcinogenesis. Early growth response gene 1 (Egr-1) is a crucial regulator of cell growth, differentiation, and survival, which is known to play a role in carcinogenesis and cancer...

Modern engines are cooled by complex air and liquid cooling systems that manage the flow of high temperature air, gases and coolants, and house critical thermal management components. Plastics, many supplied by DuPont, are playing an increasingly important role in key cooling system parts including thermostat and heater housings, outlet and inlet ports, valves, cross-overs, coolant pumps, water...

Egr-3 is an immediate-early primary response gene encoding a zinc finger transcription factor. We cloned the human Egr-3 genomic locus including greater than 1100 bp of the 5' flanking region and analyzed this region for putative cis-acting elements. The GC-rich promoter forms part of a representative CpG island that extends into the genomic locus. The Egr-3 promoter contains a region of TATA h...

Water electrolyzed hydroxyl gas (HHO or Brown gas) and compressed natural (CNG) are the important promising alternatives to pure fossil fuels. The global concern is about GHG emission in environment ambient air pollution steered by mass consumption of fuels automobile industries power sectors. In this study, combustion, performance characteristics HHO CNG mixtures supplied intake manifold compr...

In this study, the effect of adding hydrogen to natural gas and EGR ratio was conducted on a diesel engine investigate performance exhaust gases by AVL Fire multi-domain simulation software. For investigation, mixture fuel replaced fuel. The percentage in blend changed from 0% 40%. compression converted 17:1 15:1. ratios were three steps 5%, 10%, 15%, with different speeds 1000 1800 RPM. Gaussi...

High-pressure isobaric combustion adopted in the double compression expansion engine (DCEE) has prospect to achieve higher thermal efficiency compared conventional diesel combustion. This work numerically explored effects of various injection strategies on and emission characteristics The study developed a mathematical model predict rate profile. After validations, extensive simulations were co...

Monoamine oxidases (MAO) A and B deaminate a number of biogenic amines. Aberrant expression of MAO is implicated in several psychiatric and neurogenerative disorders. In this study, we have shown that phorbol 12-myristate 13-acetate (PMA) increases human MAO B, but not MAO A, gene expression. The sequence between -246 and -225 bp consists of overlapping binding sites (Sp1/Egr-1/Sp1) that are re...

The redox-based regulation of gene expression is one of the fundamental mechanisms of cellular functions, and hydrogen peroxide seems to act as an intracellular second messenger of signal transduction of cytokines. Hydrogen peroxide at non-toxic doses induced the accumulation of mRNA for the early growth response-1 (egr-1) gene in mouse osteoblastic cells. The Egr-1 protein is a transcription f...