Yitzhak Rabin was a unique man in so many ways. He was introspective and analytical, incisive and sagacious, discerning and decisive. He could be boldly forthright and extraordinarily self-effacing. His intellectual integrity could cut like a scalpel. As a soldier he was a brilliant strategist and as a peace maker he was a visionary. His courage was rock-like. He was a rare leader of Israel and...

THE Council of the Ulster MIedical Society and the Editorial Committee of the ULSTER MEI)ICAL JOURNAL have received, andl accepte(l with very great regret, the resignation of Dr. R. H. Hunter from the office of Editor. Dr. Iliunter has earne(d the very warnm thanks of tJlster (loctors for his work, a1n(d the fact that it has been a labour of love in nIo way lessens either its effort orI its val...

Enterohemorrhagic Escherichia coli, enteropathogenic E. coli, and Citrobacter rodentium are highly adapted enteropathogens that successfully colonize their host's gastrointestinal tract via the formation of attaching and effacing (A/E) lesions. These pathogens utilize a type III secretion system (TTSS) apparatus, encoded by the locus of enterocyte effacement, to translocate bacterial effector p...

Attaching and effacing Escherichia coli (AEEC) are extracellular pathogens that induce the formation of actin-rich structures at their sites of attachment to eukaryotic host cells. We analysed whether small GTP-binding proteins of the Rho- and Ras-subfamilies, which control the cellular actin system, are essential for these bacterial-induced microfilament reorganizations. For this purpose we sp...

Attaching and effacing (AE) bacteria are a diverse group of gastrointestinal pathogens, comprising members of four genera, that cause the intestinal epithelial microvilli to be replaced with raised clusters of filamentous actin that conform to the surface of attached bacteria. We have cloned a 35.4 kb 'pathogenicity island' from the prototype AE bacterium, enteropathogenic Escherichia coli, con...

THE Council of the Ulster MIedical Society and the Editorial Committee of the ULSTER MEI)ICAL JOURNAL have received, andl accepte(l with very great regret, the resignation of Dr. R. H. Hunter from the office of Editor. Dr. Iliunter has earne(d the very warnm thanks of tJlster (loctors for his work, a1n(d the fact that it has been a labour of love in nIo way lessens either its effort orI its val...

In the present study, we compared two strains of serotypes 088:H25 and 0145:H45 with an enteropathogenic Escherichia coli (EPEC) adherence factor-positive (EAF+) strain of the classic enteropathogenic E. coli serotype 0111ab:H2 for their association with HeLa cells and with biopsies of human duodenal mucosa. Both strains not belonging to the classic EPEC serotype showed virulence properties sim...

The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) causes severe diarrhea, but the influence of the gut microbiota on EHEC infection is largely unknown. A predominant member of the microbiota, Bacteroides thetaiotaomicron (Bt), is resident at EHEC attachment sites. We show that Bt enhances EHEC virulence gene expression through the transcription factor Cra, which is functionally sen...

Attaching and effacing Escherichia coli (AEEC) strains cause histopathological alterations termed “attaching and effacing (A/E) lesions” (8). The ability to cause A/E lesions is encoded on a large bacterial chromosomal pathogenicity island, the locus of enterocyte effacement (LEE). The central portion of LEE encodes intimin (Eae, 94to 97-kDa outer membrane protein) and Tir, the intimin receptor...