During the last decades, many studies reported that male reproductive disorders are increasing among humans. It is currently acknowledged that these abnormalities can result from fetal exposure to environmental chemicals that are progressively becoming more concentrated and widespread in our environment. Among the chemicals present in the environment (air, water, food, and many consumer product...

The role of the rotational dynamics of actin filaments in their interaction with myosin was studied by comparing the effect of myosin subfragment 1 (S1) with two other structural perturbations, which have substantial inhibitory effects on activation of myosin ATPase and in vitro motility of F-actin: (1) binding of the antibody fragment Fab(1-7) against the first seven N-terminal residues and (2...

In glycoside hydrolase family 66 (see http://afmb.cnrs-mrs.fr/CAZY/), cyclodextran glucanotransferase (CITase) is the only transglycosylation enzyme, all the other family 66 enzymes being dextranases. To analyze the catalytic amino acids of CITase, we modified CITase chemically from the T-3040 strain of Bacillus circulans with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). EDC inactivate...

Electronic Data Capturing offers a significantly higher ad-hoc quality of study data at the time of entry, which is specifically important for post-marketing type studies where resources for subsequent data cleaning are limited. Internet-based tools provide a good solution to these scenarios as typically large numbers of centres and/or doctors are involved. But while the deployment of Internet-...

The high degree of degradation and the low angiogenic capabilities of temporary tissue substitutes still represent a major challenge in the field of tissue engineering. In an attempt to meet some of these challenges we covalently incorporated Astragalus polysaccharides, a plant extract with angiogenic properties, into collagen matrices. This contribution aims at developing a three-dimensional s...

BackgroundThe treatment strategy of femoral shaft fractures in polytraumatised patients has evolved over the years and led to improved outcomes for these patients. However, there is still controversy regarding optimal surgical care can differ markedly from one country another. We investigate (Early Definitive Care (EDC) or Damage Control Orthopaedics (DCO)) implemented severely injured with tre...

background: educational development center (edc) establishment is one of the procedures to improve quality of medical education. as positive knowledge and attitude of lecturers and students are essential factors to gain access to goals of these centers, the aim of this project was to assess knowledge and satisfaction of faculty members and students about edc activities, babol-2010. methods: thi...

in this study cellular phosphatase activity, referred to as enzyme developed color (edc) assay, was used for an in vitro assessment of cell proliferation and cytotoxicity. optimum conditions were established and found to be 10 x103 cells / well at 37°c and 60 min incubation (for developing color). under the same conditions a direct correlation between optical density (00) and cell number was ob...

Air bubbles in ice cores play an essential role in climate research, not only because they contain samples of the palaeoatmosphere, but also because their shape, size and distribution provide information about the past firn structure and the embedding of climate records into deep ice cores. In this context, we present profiles of average bubble size and bubble number for the entire EDML (Antarc...

The impact of endocrine disrupting chemical (EDC) exposure on human health is receiving increasingly focused attention. The prototypical EDC bisphenol A (BPA) is an estrogenic high-production chemical used primarily as a monomer for the production of polycarbonate and epoxy resins. It is now well established that there is ubiquitous human exposure to BPA. In the general population, exposure to ...