Viperbite is often associated with severe local toxicity, including progressive hemorrhage and myotoxicity, persistent even after the administration of anti-snake venom (ASV). In the recent past, investigations have revealed the orchestrated actions of Zn2+ metalloproteases (Zn2+MPs), phospholipase A2s (PLA2s) and hyaluronidases (HYs) in the onset and progression of local toxicity from the bitt...

BACKGROUND We showed that mitochondrial coupling factor 6 (CF6), an endogenous inhibitor of prostacyclin synthesis, is present in the systemic circulation as a pressor substance in rats. We investigated the possibility of vascular endothelial cells as a source of circulating CF6. METHODS AND RESULTS We used 2 cultured endothelial cell lines, human umbilical vein endothelial cells (HUVECs) and...

Background Interstitial myocardial fibrosis is a histological hallmark of non-ischemic dilated cardiomyopathy (DCM), and may play an important role in adverse remodelling and progressive systolic dysfunction. T1-mapping enables noninvasive assessment of diffuse fibrosis by quantification of myocardial extracellular volume fraction (ECV). We hypothesized that CMR would identify a raised ECV in D...

BACKGROUND The concentration of gadopentetate dimeglumine in myocardium and blood can be assessed from T1 measurements and can be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping. M...

Background It has been shown that the concentration of gadopentetate dimeglumine (GdDTPA) in myocardium and blood can be assessed from T1 measurements, and be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small animal model could be quantitatively assessed by measuring myocardial ECV using small animal Look-Locker inver...

BACKGROUND Breech presentation occurs in 3 to 4% of all term pregnancies. External cephalic version (ECV) is proven effective to prevent vaginal breech deliveries and therefore it is recommended by clinical guidelines of the Royal Dutch Organisation for Midwives (KNOV) and the Dutch Society for Obstetrics and Gynaecology (NVOG). Implementation of ECV does not exceed 50 to 60% and probably less....

Introducción: Las enfermedades cardiovasculares (ECV) son un grupo de trastornos que afectan el corazón y los vasos sanguíneos. El desarrollo las ECV está asociado a factores riesgo tales como edad, la herencia genética, falta actividad física, tabaquismo, hipertensión arterial dislipidemia. Por su alta prevalencia nivel mundial, muchas personas recurren especies vegetales para tratar sus padec...

IMPORTANCE Although white matter hyperintensities (WMHs) are associated with the risk for Alzheimer disease, it is unknown whether they represent an independent source of impairment or interact with known markers of disease. OBJECTIVE To examine the degree to which WMHs predict aggressive cognitive decline among individuals with mild cognitive impairment, either independently or by modifying ...

Background Development of diffuse myocardial fibrosis in aortic stenosis (AS) has been associated with an adverse prognosis. Measurement of extracellular volume (ECV) from T1 mapping contrast magnetic resonance (CMR), has been recently validated as a non-invasive method for assessment of such diffuse myocardial fibrosis.Our objective was to evaluate the functional consequences of diffuse myocar...

Background CMR techniques are increasingly being used to evaluate myocardial extracellular volume (ECV). In the most commonly applied method, ECV is quantified using haematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus. The technique is based on a two-compartment model, assuming contrast kinetic effects to be negligible due to a dynamic equilibrium betw...