Sepsis is a leading cause of death in the United States and worldwide. Early recognition and effective management are essential for improved outcome. However, early recognition is impeded by lack of clinically utilized biomarkers. Complement factors play important roles in the mechanisms leading to sepsis and can potentially serve as early markers of sepsis and of sepsis severity and outcome. T...

INTRODUCTION Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects the microvasculature, yet the relationships between RAS and organ injury in clinical sepsis remain unclear. We tested our hypothesis that systemic RAS mediators are associated with dy...

Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis seem to be similar: avoidance, attention, and speed, if necessary. The present review discusses the current status of the systemic inflammatory response syndrome (SIRS) criteria, which...

Background Despite decades of research, sepsis remains a leading cause mortality and morbidity in intensive care units worldwide. The key to effective management patient outcome is early detection, for which no prospectively validated machine learning prediction algorithm currently available clinical use Europe. Objective We aimed develop high-performance based on routinely collected unit data,...

Sepsis is associated with dysregulated cortisol secretion, leading to abnormal levels of in the blood. In early stages condition, are typically elevated due increased secretion from adrenal glands. However, as disease progresses, may decline impaired function, relative insufficiency. The latter thought be caused by a combination factors, including decreased production corticotropin-releasing ho...

Aim: Sepsis is a life-threatening organ dysfunction accompanied by dysregulated host response to infection. Patients with sepsis may present different clinical manifestations, and there no gold standard diagnostic test. Early diagnosis rapid treatment result in decrease sepsis-related deaths. Quick Sequential Organ Failure Assessment (qSOFA) scoring system used diagnosing through evaluation at ...

Sepsis, severe sepsis and septic shock are among the most common conditions handled in the emergency department (ED). According to new Sepsis Guidelines, early diagnosis and treatment are the keys to improve survival. Plasma C-reactive protein (CRP) and procalcitonin (PCT) levels, when associated with documented or suspected infection, are now part of the definitions of sepsis. Blood culture is...

OBJECTIVE The purpose of this study was to compare maternal characteristics and neonatal morbidity and mortality rates that are associated with early-onset neonatal sepsis that is caused by group B Streptococcus and Escherichia coli. STUDY DESIGN This was a retrospective review of newborn infants with a positive blood culture (and/or cerebrospinal fluid) that was positive for either E coli or...

The spectrum of organisms causing sepsis is different in developing countries. Data on the recent trends of organisms causing sepsis are limited. This study was conducted in a tertiary care neonatal unit in Northern India. All inborn babies with blood-culture-positive sepsis from 1995 to 2006 were divided into two epochs, viz. 1995 to 1998 (epoch I) and 2001 to 2006 (epoch II). Organisms were g...

The use of corticosteroids as adjunctive therapy for severe sepsis and septic shock has been a source of controversy for the past 35 years. Despite a wealth of preclinical data supporting both survival and physiologic benefit for early steroid use, the data in human sepsis have been much less convincing. There have even been reports suggesting the potential for harm associated with the administ...