Most studies of phenotypic selection do not estimate selection or fitness surfaces for multiple components of fitness within a unified statistical framework. This makes it difficult or impossible to assess how selection operates on traits through variation in multiple components of fitness. We describe a new generation of aster models that can evaluate phenotypic selection by accounting for tim...

The aim of this paper is to identify Genetic Algorithms (GAs) which perform well over a range of continuous and smooth multimodal real-variable functions. In our study, we focus on testing GAs combining three classes of genetic operators: selection, crossover and replacement. The approach followed is time-constrained and thus our stopping criterion is a fixed number of generations. Results show...

Cholangiocarcinoma (CC) is a primary malignancy that arises from cholangiocytes, the epithelial cells lining the bile duct livers. The worldwide incidence of CC is increasing and despite of combined therapeutic strategies, its prognosis remains poor. Till now surgery remains the only curative treatment modality. Over the past years, several important studies have yielded new insights into the m...

It is well known that the boosting-like algorithms, such as AdaBoost and many of its modifications, may over-fit the training data when the number of boosting iteration becomes large. Therefore, how to stop a boosting algorithm at an appropriate iteration time is a longstanding problem for the past decade (see Meir and Rastch (2003)). Bühlmann and Yu (2005) apply model selection criteria to est...

BACKGROUND Adoptive T cell immunotherapy (ATCT) for cancer entails infusing patients with T cells that recognise and destroy tumour cells. Efficient engraftment of T cells and persistence in the circulation correlate with favourable clinical outcomes. T cells of early differentiation possess an increased capacity for proliferation and therefore persistence, using these cells for ATCT could ther...

OBJECTIVES To review studies on newborn hearing screening in Hong Kong and the current evidence on the cost-effectiveness of universal newborn hearing screening programmes and to determine their value and the best model for such a programme in Hong Kong. DATA SOURCE Medline literature search (1985-2004), local reports and abstracts available to the author. STUDY SELECTION Literature and dat...

background: the immunomagnetic separation technique is the basis of monocyte isolation and further generation of monocyte-derived dendritic cells. objective: to compare the efficiency of monocyte positive and negative separation, concentration of beads, and their impact on generated dendritic cells. methods: monocytes were obtained using monoclonal antibody-coated magnetic beads followed the fi...

Numerous studies have demonstrated that selective attention to color is associated with a larger neural response under attend than ignore conditions, but have not addressed whether this difference reflects enhanced activity under attend or suppressed activity under ignore. In this study, a color-neutral condition was included, which presented stimuli physically identical to those under attend a...

considering the major change occurred in business cells from plant to “chain” and the critical need to choose the best partners to form the supply chain for competing in today’s business setting, one of the vital decisions made at the early steps of constructing a business is supplier selection. given the fact that the early decisions are inherently strategic and therefore hard and costly to ch...