Background and objective: Periodontal disease is one of the common inflammatory diseases with complex etiology and is multifactorial in origin.Several enzymes are evaluated for the early diagnosis of periodontal disease. The enzyme ALP plays a role in bone metabolism. In the periodontium, ALP is very important enzyme as it is part of normal turnover of periodontal ligament, root cementum, and b...

A classification for advanced alveolar bone loss in children and adolescents is presented for the purpose of clarifying the oftentimes confusing terminology that presently exists. Page’s definiton of prepubertal periodontitis is advocated, and a representative case is presented. The classic definition of periodontosis is "a disease of the periodontium occurring in an otherwise healthy adolescen...

BACKGROUND Periodontitis has been associated with increased risk of adverse pregnancy outcomes and elevated C-reactive protein (CRP) concentrations in non-pregnant adults. We examined the relationship between periodontitis and CRP among women who provided dental radiographs and had blood collected during early pregnancy, excluding smokers and diabetic patients. METHODS From Project Viva, an o...

OBJECTIVE Periodontal pathogens in dental plaque are the main causative agents of periodontitis and peri-implantitis. Detection of the presence of such periodontal pathogens early would serve as a useful tool in the diagnosis and treatment of this disease. Therefore, the purpose of this study was to investigate whether the periodontal pathogen levels in saliva were correlated with the periodont...

PURPOSE The purpose of the present study was to perform a pattern analysis in patients with temporomandibular disorder (TMD) resulting from unilateral mastication due to chronic periodontitis. METHODS Thirty participants with signs or symptoms of TMD who engaged in unilateral mastication due to periodontitis-related discomfort (test group) were selected. Another 30 subjects exhibiting signs o...

Human immunoglobulin G2 (IgG2) serum concentrations and the IgG2 antibody response to Actinobacillus actinomycetemcomitans can be influenced by genes, by environmental factors such as smoking, and by periodontal disease status. Examination of the IgG2 response to phosphorylcholine (PC), a response thought to be mainly induced by the C polysaccharide of Streptococcus pneumoniae, suggested that p...

Abstract Background Periodontitis is one of major oral diseases, which has no consensus on early screening tool. This study aimed to compare the association and ability S100A8 S100A9 in saliva, blood gingival crevicular fluid (GCF) for periodontitis status. Methods We recruited 149 community Korean adults, 50 or initial (NIPERIO) 99 established (PERIO). Using clinical attachment loss a panorami...

Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status...

Periodontitis is a chronic oral inflammatory disease produced by bacteria. Gingival retraction and bone and connective tissues resorption are the hallmarks of this disease. Chronic periodontitis may contribute to the risk of onset or progression of neuroinflammatory pathological conditions, such as Alzheimer's disease. The main goal of the present study was to investigate if the role of epigene...

Platelet factor 4 (PF4) and heparin (H) form PF4/H complexes, the target of the immune reaction in heparin-induced thrombocytopenia (HIT). HIT seems to be a secondary immune response as anti-PF4/H-IgG antibodies occur as early as day 4 of heparin treatment. This study investigated whether prevalent infections such as periodontitis may induce the PF4/H immune response as: (1) natural anti-PF4/H ...